(1R,3R)-RSL3
Based on 3 publication(s) in Google Scholar
(1R,3R)-RSL3 is an isomer of RSL3 (HY-100218A). RSL3 ((1S,3R)-RSL3) is an inhibitor of glutathione peroxidase 4 (GPX4) (ferroptosis activator), reduces the expression of GPX4 protein, and induces ferroptotic death of head and neck cancer cell. RSL3 increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells.
For research use only. We do not sell to patients.
- Purity: 99.05%
- CAS No.: 1219810-15-7
- Formula: C23H21ClN2O5
- Molecular Weight:440.88
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Ferroptosis Compound Library
HY-L051
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Cuproptosis Compound Library
HY-L133
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Cell Death Library
HY-L162
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Mitophagy Compound Library
HY-L180
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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NF-κB Signaling Compound Library
HY-L014
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Anti-Cancer Compound Library
HY-L025
Publications Citing Use of MedChemExpress (MCE) (1R,3R)-RSL3
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Biological Activity
Chemical Information
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CAS No. 1219810-15-7
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Appearance Solid
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Molecular Weight 440.88
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Formula C23H21ClN2O5
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Color Off-white to light yellow
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SMILES
O=C([C@H]1CC2=C([C@@H](C3=CC=C(C(OC)=O)C=C3)N1C(CCl)=O)NC4=C2C=CC=C4)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
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Antimicrob Agents Chemother
Synergistic activity of RSL3 and Pyrimethamine to inhibit the proliferation of Plasmodium falciparum. [Abstract]2025 Aug 18:e0047125. PMID: 40823867 -
Front Biosci (Landmark Ed)
Immune Characteristics of eQTL and Gene Risk Model and the Inhibitory Effect of DCTD and RRAS on Ferroptosis in Glioblastoma. [Abstract]2025 Aug 30;30(8):42844. PMID: 40917066 -
Solvent & Solubility
DMSO : 100 mg/mL (226.82 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (280 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2682 mL | 11.3410 mL | 22.6819 mL | 56.7048 mL |
| 5 mM | 0.4536 mL | 2.2682 mL | 4.5364 mL | 11.3410 mL | |
| 10 mM | 0.2268 mL | 1.1341 mL | 2.2682 mL | 5.6705 mL | |
| 15 mM | 0.1512 mL | 0.7561 mL | 1.5121 mL | 3.7803 mL | |
| 20 mM | 0.1134 mL | 0.5670 mL | 1.1341 mL | 2.8352 mL | |
| 25 mM | 0.0907 mL | 0.4536 mL | 0.9073 mL | 2.2682 mL | |
| 30 mM | 0.0756 mL | 0.3780 mL | 0.7561 mL | 1.8902 mL | |
| 40 mM | 0.0567 mL | 0.2835 mL | 0.5670 mL | 1.4176 mL | |
| 50 mM | 0.0454 mL | 0.2268 mL | 0.4536 mL | 1.1341 mL | |
| 60 mM | 0.0378 mL | 0.1890 mL | 0.3780 mL | 0.9451 mL | |
| 80 mM | 0.0284 mL | 0.1418 mL | 0.2835 mL | 0.7088 mL | |
| 100 mM | 0.0227 mL | 0.1134 mL | 0.2268 mL | 0.5670 mL |
(1R,3R)-RSL3 Related Classifications
HY-100218C Related Classifications
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