Drug Isomer
Drug Isomer
Drug isomers are compounds with the same molecular formula but different atomic arrangements or spatial configurations. They are divided into structural isomers and stereoisomers, and have different biological activities, safety and metabolic characteristics. Drug isomers can be used as drug improvement groups or drug efficacy control groups. For example, Carvedilol has higher bioavailability and better safety than (R)-Carvedilol.
References:
- [1]. Evans AM, et al. Comparative pharmacology of S(+)-ibuprofen and (RS)-ibuprofen. Clin Rheumatol. 2001 Nov;20 Suppl 1:S9-14. [Content Brief]
- [2]. Andersson T. Single-isomer drugs: true therapeutic advances. Clin Pharmacokinet. 2004;43(5):279-85. [Content Brief]
- [3]. Chhabra N, et al. A review of drug isomerism and its significance. Int J Appl Basic Med Res. 2013 Jan;3(1):16-8. [Content Brief]
All Product Categories
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Drug Isomer Related Products (557)
Related Products (557)
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5-Fluoro PB-22 N-(3-fluoropentyl) isomer
0 ImagesCat. No.: HY-172044CAS No.: 2365471-07-25-Fluoro PB-22 N-(3-fluoropentyl) isomer is a structural isomer of 5-Fluoro PB-22.
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5-Fluoro PB-22 5-hydroxyisoquinoline isomer
0 ImagesCat. No.: HY-172047CAS No.: 2365471-16-35-Fluoro PB-22 5-hydroxyisoquinoline isomer is a structural isomer of 5-Fluoro PB-22.
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8-Iso-17-phenyl trinor prostaglandin F2β
0 ImagesCat. No.: HY-172634Synonyms: 8-Iso-17-phenyl PGF2β8-Iso-17-phenyl trinor prostaglandin F2β is an isomer of Bimatoprost (HY-B0191). Bimatoprost is a prostaglandin analog. Bimatoprost lowers intraocular pressure by regulating scleral and trabecular outflow.
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(Rac)-Salvianic acid A
0 ImagesSynonyms: (Rac)-Danshensu; (Rac)-Tanshinol(Rac)-Salvianic acid A ((Rac)-Danshensu) is the racemate of Salvianic acid A (HY-N1913). Salvianic acid A, an orally active phenolic compound, can induce Nrf2/HO-1 activation and inhibition of NF-κB pathway. Danshensu has anti-oxidation, anti-apoptosis, anti-lung inflammatory and has the potential for COVID-19, cardiovascular and cerebrovascular diseases research.
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(1S,2S)-2-PCCA hydrochloride (Standard)
0 ImagesCat. No.: HY-100013B1RCAS No.: 1609563-70-3(1S,2S)-2-PCCA (hydrochloride) (Standard) is the analytical standard of (1S,2S)-2-PCCA (hydrochloride) (HY-100013B1). This product is intended for research and analytical applications. (1S,2S)-2-PCCA hydrochloride is a less active diastereomer of 2-PCCA. 2-PCCA is a GPR88 receptor agonist, and inhibits GPR88-mediated cAMP production, with an EC50 of 116 nM in HEK293 cells.
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(22R)-Budesonide-d6
0 ImagesCat. No.: HY-125922SSynonyms: Dexbudesonide-d6; (22R)-BUD-d6(22R)-Budesonide-d6 (Dexbudesonide-d6) is deuterium labeled (22R)-Budesonide. (22R)-Budesonide ((22R)-BUD) is the (22R)-enantiomer of Budesonide (HY-13580). (22R)-Budesonide is a non-halogenated glucocorticoid with high local anti-inflammatory activity.
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KI696 isomer (Standard)
0 ImagesCat. No.: HY-101140ARCAS No.: 1799974-69-8KI696 isomer (Standard) is the analytical standard of KI696 isomer (HY-101140A). This product is intended for research and analytical applications. KI696 isomer is an isomer of KI696 (HY-101140). KI696 is a selective KEAP1/NRF2 protein-protein interaction inhibitor with a human Kd value of 1.3 nM. KI696 acts by competitively occupying the NRF2-binding pocket of the KEAP1 Kelch domain. KI696 blocks KEAP1-mediated ubiquitination and degradation of NRF2, promotes the translocation of NRF2 to the nucleus, activates the expression of downstream antioxidant genes, increases intracellular glutathione levels, and alleviates oxidative stress-induced cell damage and inflammatory cell infiltration in the lungs. KI696 reduces ozone-induced pulmonary oxidative damage and inflammatory cell accumulation in rats, and upregulates pulmonary antioxidant genes. KI696 can be used in research related to chronic obstructive pulmonary disease, oxidative stress and inflammation.
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PB-22 6-Hydroxyquinoline isomer
0 ImagesCat. No.: HY-172041CAS No.: 2365471-56-1PB-22 6-Hydroxyquinoline isomer is a structural isomer of PB-22. PB-22 is a cannabinoid.
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(R)-Lotaustralin
0 ImagesCat. No.: HY-W698586CAS No.: 534-67-8(R)-Lotaustralin is a cyanogenic compound derived from Manihot Utilissima, playing a role in the plant's biological defense mechanism. When plant tissue is damaged, (R)-Lotaustralin is hydrolyzed by enzymes such as linamarase, releasing cyanide and thereby exerting a toxic defensive effect.
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(E/Z)-Diniconazole
0 ImagesCat. No.: HY-B1948ACAS No.: 70217-36-6Synonyms: (E/Z)-S-3308(E/Z)-Diniconazole ((E/Z)-S-3308) is an isomer of Diniconazole (HY-B1948). Diniconazole (S-3308) is a fungicide that can be used in research on the control of plant fungal diseases and plant growth regulation.
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ent-DOPC
0 ImagesCat. No.: HY-N15913CAS No.: 84366-67-6ent-DOPC is a glycerol chirality isomer of 1,2-Dioleoyl-sn-glycero-3-phosphocholine (DOPC) (HY-113424A).
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(R)-CXCR4 modulator-2
0 ImagesCat. No.: HY-146054ACAS No.: 2488943-55-9
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(+)-Monomorine I
0 ImagesCat. No.: HY-N22024CAS No.: 53447-44-2(+)-Monomorine I is an Indolizidine alkaloid and the enantiomer of Monomorine I. Monomorine I is the trail pheromone of the pharaoh ant Monomorium oharoanasl.
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C24 (2'(S)-Hydroxy) dihydro ceramide (d18:0/24:0)
0 ImagesCat. No.: HY-172938CAS No.: 2752732-45-7C24 (2'(S)-Hydroxy) dihydro ceramide (d18:0/24:0) is the 2S-isomer of C24 Dihydro ceramide (d18:0/24:0) (HY-156206) and the S-isomer of C24 (2'(R)-Hydroxy) dihydro ceramide (d18:0/24:0) (HY-158952).
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(9E,11E)-9,11-Octadecadienoic acid methyl ester
0 ImagesCat. No.: HY-121952CAS No.: 13038-47-6(9E,11E)-9,11-Octadecadienoic acid methyl ester is an isomer of 9(Z),11(E),13(E)-octadecatrienoic acid methyl ester and the methyl ester form of 9(Z),11(E),13(Z)-octadecatrienoic acid, which is found in wild growing pomegranate seed oil.
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(S)-JNJ-1013
0 ImagesCat. No.: HY-153188ACAS No.: 2755075-91-1(S)-JNJ-1013 is an isomer of IRAK1 PROTAC degrader JNJ-1013 (HY-153188). (S)-JNJ-1013 loses VHL binding affinity (IC50 >10 μM) and shows no significant IRAK1 degradation activity (DC50 > 10 μM). (S)-JNJ-1013 selectively inhibits IRAK1 with an IC50 of 79 nM. (S)-JNJ-1013 can be used to study cancers dependent on the scaffolding function of IRAK1.
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(±)-Lavandulyl acetate (Standard)
0 ImagesCat. No.: HY-117419ARCAS No.: 25905-14-0(±)-Lavandulyl acetate (Standard) is the analytical standard of (±)-Lavandulyl acetate (HY-117419A). This product is intended for research and analytical applications. (±)-Lavandulyl acetate is an isomer of (-)-Lavandulyl acetate (HY-117419). (-)-Lavandulyl acetate is a nature product that can be found in Lavandula angustifolia. (-)-Lavandulyl acetate shows toxicity for mosquito vectors. (-)-Lavandulyl acetate can be used as mosquito larvicide.
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(R)-Cicaprost
0 ImagesCat. No.: HY-106099CAS No.: 95722-07-9Synonyms: (R)-ZK 96480(R)-Cicaprost ((R)-ZK 96480) is an isomer of Cicaprost (HY-19583). Cicaprost is an orally active prostacyclin analog. Cicaprost inhibits platelet aggregation and release, and induces vasodilation. Cicaprost can be used in research related to breast cancer and pulmonary arterial hypertension.
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PB-22 7-Hydroxyquinoline isomer
0 ImagesCat. No.: HY-172042CAS No.: 1629062-76-5PB-22 7-Hydroxyquinoline isomer is a structural isomer of PB-22. PB-22 is a cannabinoid.
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(R)-Colchicine
0 ImagesCat. No.: HY-W741136CAS No.: 75520-89-7(R)-Colchicine is the R-isomer of Colchicine (HY-16569). Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research.
