(Rac)-[6]-Gingerol
(Rac)-[6]-Gingerol is a natural product. (Rac)-[6]-Gingerol can be isolated from rhizomes of Z. officinale. (Rac)-[6]-Gingerol shows moderate anticancer activity against lung cancer, ovarian cancer, melanoma, and colon cancer.
For research use only. We do not sell to patients.
- CAS No.: 39886-76-5
- Formula: C17H26O4
- Molecular Weight:294.39
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
![(Rac)-[6]-Gingerol Chemical Structure](https://file.medchemexpress.com/product_pic/hy-100187.gif "Click to View (Rac)-[6]-Gingerol Chemical Structure")
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
45.05 μM
Compound: N1
|
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by WST1 assay
Cytotoxicity against human HCT116 cells assessed as reduction in cell viability after 48 hrs by WST1 assay
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[PMID: 28065501] |
| HEK293 | EC50 |
10.4 μM
Compound: 1a, Racemic [6]-gingerol
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Agonist activity at rat TRPA1 ion channel expressed in HEK293 cells assessed as calcium influx by fluo-4-Am-based fluorimetry
Agonist activity at rat TRPA1 ion channel expressed in HEK293 cells assessed as calcium influx by fluo-4-Am-based fluorimetry
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[PMID: 22257892] |
| HEK293 | EC50 |
3.3 μM
Compound: 1a, Racemic [6]-gingerol
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Agonist activity at human TRPV1 ion channel expressed in HEK293 cells assessed as calcium influx by fluo-4-Am-based fluorimetry
Agonist activity at human TRPV1 ion channel expressed in HEK293 cells assessed as calcium influx by fluo-4-Am-based fluorimetry
|
[PMID: 22257892] |
| HEK293 | IC50 |
>100 μM
Compound: 1a, Racemic [6]-gingerol
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Antagonist activity at rat TRPA1 ion channel expressed in HEK293 cells assessed as inhibition of AITC-induced calcium influx incubated for 5 mins prior to AITC-induction by fluo-4-AM-based fluorimetry
Antagonist activity at rat TRPA1 ion channel expressed in HEK293 cells assessed as inhibition of AITC-induced calcium influx incubated for 5 mins prior to AITC-induction by fluo-4-AM-based fluorimetry
|
[PMID: 22257892] |
| HEK293 | IC50 |
5 μM
Compound: 1a, Racemic [6]-gingerol
|
Antagonist activity at human TRPV1 ion channel expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium influx incubated for 5 mins prior to capsicin-induction by fluo-4-AM-based fluorimetry
Antagonist activity at human TRPV1 ion channel expressed in HEK293 cells assessed as inhibition of capsaicin-induced calcium influx incubated for 5 mins prior to capsicin-induction by fluo-4-AM-based fluorimetry
|
[PMID: 22257892] |
Chemical Information
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CAS No. 39886-76-5
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Molecular Weight 294.39
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Formula C17H26O4
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SMILES
O=C(CCC1=CC=C(O)C(OC)=C1)CC(O)CCCCC
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Synonyms
(±)-[6]-Gingerol
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(Rac)-[6]-Gingerol Related Classifications
HY-100187 Related Classifications
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