Cytotoxic components from the dried rhizomes of Zingiber officinale Roscoe

  • Arch Pharm Res. 2008 Apr;31(4):415-8. doi: 10.1007/s12272-001-1172-y.
Ju Sin Kim  1 ,  Sa Im Lee ,  Hye Won Park ,  Jae Heon Yang ,  Tae-Yong Shin ,  Youn-Chul Kim ,  Nam-In Baek ,  Sung-Hoon Kim ,  Sang Un Choi ,  Byoung-Mog Kwon ,  Kang-Hyun Leem ,  Mun Yhung Jung ,  Dae Keun Kim
Affiliations
  • 1. College of Pharmacy, Woosuk University, Samrye, Korea.
PMID: 18449496 DOI: 10.1007/s12272-001-1172-y
Abstract

Five compounds were isolated from the chloroform-soluble fraction of the methanolic extract of the dried rhizomes of Zingiber officinale (Zingiberaceae) through repeated column chromatography. Their chemical structures were elucidated as 4-, 6-, 8-, and 10-gingerols, and 6-shogaol using spectroscopic analysis. Among the five isolated compounds, 6-shogaol exhibited the most potent cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells. 6-shogaol inhibited proliferation of the transgenic mouse ovarian Cancer cell lines, C1 (genotype: p53(-/-), c-Myc, K-Ras) and C2 (genotype: p53(-/-), c-Myc, Akt), with ED(50) values of 0.58 microM (C1) and 10.7 microM (C2).

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