Isotope-Labeled Compounds

Isotope-labeled compounds are chemical substances in which some atoms in their molecules are replaced by isotope atoms. The range of stable isotope products can cover from gases to complex molecules. Isotope-labeled compounds could provide a site-specific investigation of structures, making molecules easily detectable by mass spectrometry and NMR, and maintaining the physico-chemical properties of the target molecule at the same time. MCE isotope-labeled compounds are all stable isotope-labeled compounds and are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes. Stable isotope-labeled products are now getting more and more popular among scientists. The scope of application is gradually penetrating into various scientific fields, such as life sciences, food and medicine, agriculture, environment, geology, etc. Stable isotope-labeled compounds have a wide range of applications in the Life Science areas, such as Metabolomics, Proteomics, Clinical studies, Deuterium drugs, etc.

Isotope-Labeled Compounds Inhibitors (4)

Isotope-Labeled Compounds Produits associés (10876):

Cat. No.	Nom du produit	Effet	Pureté	Chemical Structure

HY-17494S

(Rac)-Timolol-d₅ maleate		99.9%
rac Timolol-d₅ (maleate) is a labelled racemic (S)-Timolol maleate. (S)-Timolol Maleate (L-714,465 Maleate) is a non-cardioselective hydrophilic β-adrenoceptor blocker. (S)-Timolol Maleate is widely used as standard medication for intraocular pressure (glaucoma) by preventing the production of aqueous humor. (S)-Timolol Maleate can be used for hypertension, angina pectoris and myocardial infarction.

HY-59137S

1-Methylimidazole-d₆		98.77%
1-Methylimidazole-d₆ is the deuterium labeled 1-Methylimidazole. 1-Methylimidazole acts as a membrane performance regulator that promotes the formation of reverse osmosis membranes with a dense ultra-thin polyamide layer. Such membranes exhibit higher flux and salt rejection rate, while also conferring excellent pH stability to the membrane. 1-Methylimidazole can serve as a ligand for ruthenium (II) complexes to construct metal-based anticancer agents.

HY-W654255

Mandelic Acid-¹³C₈		98.17%
Mandelic Acid-¹³C₈ ((±)-Mandelic acid-¹³C₈) is the ¹³C-labeled Mandelic acid (HY-W015591). Mandelic acid ((±)-Mandelic acid), an alpha-hydroxycarboxylic acid, has been widely used as an intermediate of pharmaceutical and fine chemicals. Mandelic acid shows antimicrobial activity and has been used for the research of urinary tract infections and vaginal trichomoniasis. Mandelic acid exhibits high sperm-immobilizing activity and low vaginal irritation.

HY-B0612DS1

Lercanidipine-d₃ hydrochloride		98.26%
Lercanidipine-d₃ (hydrochloride) is the deuterium labeled Lercanidipine. Lercanidipine is a lipophilic third-generation dihydropyridine-calcium channel blocker (DHP-CCB). Lercanidipine has long lasting antihypertensive action and reno-protective effect.

HY-119708S

Ensifentrine-d₆
Ensifentrine-d₆ (RPL-554-d₆) is deuterium labeled Ensifentrine. Ensifentrine (RPL-554) is an inhaled first-in-class dual inhibitor of phosphodiesterase 3 (PDE3) and PDE4 with IC₅₀s of 0.4 nM and 1479 nM, respectively. Ensifentrine has bronchoprotective and anti-inflammatory activities. Ensifentrine can be used for chronic obstructive pulmonary disease (COPD) research.

HY-Y0772S

2-Bromopyridine-d₄		98.40%
2-Bromopyridine-d₄ is the deuterium labeled 2-Bromopyridin.

HY-W710495

N-Acetyl-L-aspartic acid-d₃-1		≥99.0%
N-Acetyl-L-aspartic acid-d₃-1 is the deuterium labeled N-Acetyl-L-aspartic acid (HY-W710495).

HY-N7092S24

D-Fructose-¹³C₄
D-Fructose-¹³C₄ is ¹³C-labeled D-Fructose (HY-N7092). D-Fructose (D(-)-Fructose) is a natural monosaccharide found in many plants.

HY-W035361S

(Aminomethyl)phosphonic acid-d₂		99.85%
(Aminomethyl)phosphonic acid-d₂ is the deuterium labeled (Aminomethyl)phosphonic acid.

HY-W042416S

N,N-Dimethylacetamide-d₉		99.0%
N,N-Dimethylacetamide-d₉ is the deuterium labeled N,N-Dimethylacetamide. N,N-Dimethylacetamide (DMAc) is an inexpensive, common aprotic organic solvent.

HY-W109812S

Sinapyl alcohol-d₃
Sinapyl alcohol-d₃ is the deuterated labeled Sinapyl alcohol (HY-W109812). Sinapyl alcohol is an orally active anti-inflammatory and antinociceptive agent. Sinapyl alcohol reduces the expression level of inducible NO synthase and COX-2.

HY-W654329

Protionamide-d₇
Protionamide-d₇ is deuterium labeled Prothionamide. Protionamide (prothionamide) acts on tuberculosis and leprosy.

HY-W017443S2

L-Asparagine-¹³C₄,¹⁵N₂,d₃ monohydrate		99.90%
L-Asparagine-¹³C₄,¹⁵N₂,d₃ monohydrate is the deuterium, ¹³C-, and ¹⁵N-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia.

HY-B0982S

Pindolol-d₇
Pindolol-d₇ (LB-46-d7) is the deuterium labeled Pindolol. Pindolol (LB-46) is the antagonist for 5-HT 1A (K_i=33 nM) and 5-HT 1B. Pindolol is the antagonist for β1/β2-adrenergic receptor. Pindolol exhibits anti-anxiety and antidepressant effects.

HY-B0260S6

Methylprednisolone-d₃-1
Methylprednisolone-d₃-1 (U 7532-d₃-1) is the deuterium labeled Methylprednisolone (HY-B0260). Methylprednisolone (U 7532) is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels.

HY-A0248AS

Polymyxin B1-d₇ TFA		98.18%
Polymyxin B1-d₇ TFA is the deuterium labeled Polymyxin B1 TFA (HY-A0248A). Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 is the major component in Polymyxin B (HY-A0248). Polymyxin B1 can induce lysis of bacterial cells through interaction with their membranes. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment.

HY-76711S

Naltrexone-d₄		99.82%
Naltrexone-d4 is deuterium labeled Naltrexone (HY-76711). Naltrexone is an orally active, long-acting opioid receptor (opioid receptor) antagonist. Naltrexone blocks the euphoric effects of exogenous opioids and reduces alcohol craving by blocking opioid receptors (μ, κ, and δ) as well as opioid growth factor receptors. Low doses of Naltrexone are used to relieve chronic pain, treat inflammatory diseases and inhibit tumor growth, while high doses or continuous administration exert pro-inflammatory or pro-proliferative effects. Naltrexone relieves intractable pruritus caused by psoriasis, atopic dermatitis and other conditions, and its combination with Bupropion (HY-B0403) inhibits food craving, thereby reducing body weight.

HY-143664S

(±)14(15)-DiHET-d₁₁
(±)14,15-DiHETrE-d₁₁ ((±)14(15)-DiHET-d₁₁) is the deuterium labeled (±)14,15-DiHETrE (HY-143664). (±)14,15-DiHETrE is an epoxide hydrolases enzymatically hydrated metabolite of (±)14(15)-EET.

HY-151868S

Glycidyl oleate-d₅		98.79%
Glycidyl oleate-d₅ is the deuterium labeled Glycidyl oleate.

HY-15731S

Estetrol-d₄
Estetrol-d₄ is the deuterium labeled Estetrol. Estetrol, a natural estrogen synthesized exclusively during pregnancy by the human fetal liver, is a selective nuclear estrogen receptor modulator. Estetrol exerts estrogenic actions on the endometrium or the central nervous system but presents antagonistic effects on the breast.

Nom
Email *

	Sorry, but the email address you supplied was invalid.