Isotope-Labeled Compounds

Isotope-labeled compounds are chemical substances in which some atoms in their molecules are replaced by isotope atoms. The range of stable isotope products can cover from gases to complex molecules. Isotope-labeled compounds could provide a site-specific investigation of structures, making molecules easily detectable by mass spectrometry and NMR, and maintaining the physico-chemical properties of the target molecule at the same time. MCE isotope-labeled compounds are all stable isotope-labeled compounds and are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes. Stable isotope-labeled products are now getting more and more popular among scientists. The scope of application is gradually penetrating into various scientific fields, such as life sciences, food and medicine, agriculture, environment, geology, etc. Stable isotope-labeled compounds have a wide range of applications in the Life Science areas, such as Metabolomics, Proteomics, Clinical studies, Deuterium drugs, etc.

Isotope-Labeled Compounds Inhibitors (4)

Isotope-Labeled Compounds Related Products (10876):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-111647S1

N2-Methylguanosine-d₃
N2-Methylguanosine-d₃ is deuterium labeled N2-Methylguanosine (HY-111647). N2-Methylguanosine is a commonly modified nucleoside in rRNA and tRNA, with specific distributions in both E. coli rRNA and eukaryotic tRNA. N2-Methylguanosine can be found in urine. N2-Methylguanosine affects the structure and stability of RNA.

HY-146881S

Colfosceril miristate-d₂₇		99.0%
1-Myristoyl-2-myristoyl-sn-glycero-3-phosphocholine-d₂₇ is deuterium labeled 1-Myristoyl-2-myristoyl-sn-glycero-3-phosphocholine.

HY-B0174AS2

Olsalazine-d₃,¹⁵N
Olsalazine-d₃,¹⁵N is ¹⁵N and deuterated labeled Olsalazine (HY-B0174A). Olsalazine is an orally active prodrug of 5-ASA (HY-15027). Olsalazine can inhibit cells proliferation and induce apoptosis. Olsalazine can reduce DAI and MPO activity and inhibit inflammatory cytokines levels. Olsalazine can be used for the researches of cancer, inflammation and metabolic disease, such as colorectal cancer, inflammatory bowel disease (IBD) and hyperuricemic.

HY-W088589S

(S)-3-Aminopiperidine-2,6-dione-d hydrochloride
(S)-3-Aminopiperidine-2,6-dione-d hydrochloride is the deuterium labeled (S)-3-Aminopiperidine-2,6-dione hydrochloride.

HY-B0228S14

Adenosine-d₉
Adenosine-d₉ is the deuterium labeled Adenosine. Adenosine (Adenine riboside), a ubiquitous endogenous autacoid, acts through the enrollment of four G protein-coupled receptors: A1, A2A, A2B, and A3. Adenosine affects almost all aspects of cellular physio.

HY-W710306

(S)-3-Chloro-2-(palmitoyloxy)propyl oleate-d₅
(S)-3-Chloro-2-(palmitoyloxy)propyl oleate-d₅ is the deuterium labeled (S)-3-Chloro-2-(palmitoyloxy)propyl oleate.

HY-N0378S4

D-Mannitol-d₂
D-Mannitol-d₂ is the deuterium labeled D-Mannitol (HY-N0378). D-Mannitol (Mannitol) is an oral, resistant sugar widely used in the food and pharmaceutical industries to promote the absorption and retention of calcium and magnesium through cecal fermentation, while acting as a osmotic diuretic to reduce tissue edema. D-Mannitol can enhance brown fat formation, improve insulin effect, reduce blood sugar levels, And through the start the β₃-adrenergic receptor (β₃-AR), PGC1α and PKA induced by means of white fat cells into brown fat cells. D-Mannitol is commonly used to maintain osmotic pressure between the plant cytoplasm and the culture medium and protect cells when the cell wall is weakened or even removed.

HY-Y0077S

4-Isopropylaniline-d₄
4-Isopropylaniline-d₄ is the deuterium labeled 4-Isopropylaniline.

HY-W755778

3-Iodothyronamine hydrochloride-13C6
3-Iodothyronamine hydrochloride-¹³C₆ is the ¹³C-labeled 3-Iodothyronamine hydrochloride (HY-135065). 3-Iodothyronamine hydrochloride is an endogenous and rapid-acting derivative of thyroid hormone. 3-Iodothyronamine potently activates an orphan G protein-coupled receptor in vitro (TAAR1) and induced hypothermia in vivo on a rapid time scale. 3-Iodothyronamine can be used for the research of congestive heart failure.

HY-108353S

Isoprenaline-d₇ acetate
Isoprenalin-d7 acetate is an internal standard for the determination of isoproterenol by GC- or LC-MS.

HY-W013724S

Inosine-5'-diphosphate-¹⁵N₄ dilithium
Inosine-5'-diphosphate-¹⁵N₄ dilithium (IDP-¹⁵N₄ dilithium) is ¹⁵N labeled Inosine-5'-diphosphate dilithium. Inosine-5'-diphosphate (IDP) is a decoy substrate of NM23-H2. Inosine-5'-diphosphate has a superior bond capacity on GDP-binding pocket of NM23-H2 (K_D: 5.0 μM). Inosine-5'-diphosphate abrogates c-MYC transcription, induces apoptosis and G2/M cell cycle arrest by disrupting NM23-H2-Pu27-GQ interactions without affecting NM23-H2-mediated kinase properties. Inosine-5'-diphosphate has antihypoxic, antihyperthermic and antiarrhythmic activity and protects animals against the noxious effects of γ-irradiation. Inosine-5'-diphosphate can be used for cancers like Burkitt's lymphoma and cardiovascular diseases research.

HY-B0561S2

Spironolactone-d₃-1
Spironolactone-d₃-1 is deuterium labeled Spironolactone. Spironolactone (SC9420) is an orally active aldosterone mineralocorticoid receptor antagonist with an IC₅₀ of 24 nM. Spironolactone is also a potent antagonist of androgen receptor with an IC₅₀ of 77 nM. Spironolactone promotes autophagy in podocytes.

HY-176356S

KRAS 2B, Arg-¹³C₆,¹⁵N₄, Lys-¹³C₆,¹⁵N₄
KRAS 2B, Arg-¹³C₃₆, ¹⁵N₄, Lys-¹³C₆, ¹⁵N₄ is the ¹³C- and ¹⁵N-labeled KRAS 2B.

HY-N0488S2

Vincristine-d₆ sulfate
Vincristine-d₆ (sulfate) is the deuterium labeled Vincristine sulfate. Vincristine sulfate (Leurocristine; NSC-67574; 22-Oxovincaleukoblastine) is a microtubule inhibitor that disrupts microtubule polymerization by binding to β-tubulin (with a K_i of 85 nM in bovine), arrests the cell cycle and induces apoptosis. Vincristine sulfate inhibits cell replication, tumor blood flow and the proliferation of various cancer cells, while triggering effects such as oxidative stress, inflammation, calcium overload, epithelial-mesenchymal transition and peripheral neuropathic pain. Vincristine sulfate upregulates the expression of various transporters and nuclear receptors, and enriches gastric cancer stem-like cells. Vincristine sulfate is used in research related to various tumors including acute lymphoblastic leukemia, lymphoma, melanoma, gastric cancer, solid tumors and sarcomas.

HY-W751764

Dehydro Folic Acid 1,5-Dimethyl Ester-¹³C₅,¹⁵N
Dehydro Folic Acid 1,5-Dimethyl Ester-¹³C₅,¹⁵N is the ¹³C- and ¹⁵N-labeled Dehydro Folic Acid 1,5-Dimethyl Ester.

HY-146850S

(11Z,14Z,17Z)-17:0-20:3 PC-d₅
(11Z,14Z,17Z)-17:0-20:3 PC-d₅ is deuterium labeled (11Z,14Z,17Z)-17:0-20:3 PC.

HY-W751350

Cyclobenzaprine-d₆
Cyclobenzaprine-d₆ is the deuterium labeled Cyclobenzaprine. Cyclobenzaprine (MK130) hydrochloride is an orally active 5-HT₂ receptor antagonist. Cyclobenzaprine hydrochloride acts centrally, providing skeletal muscle relaxation, alleviating muscle spasms, and reducing pain. Cyclobenzaprine hydrochloride also possesses antiparasitic activity. Cyclobenzaprine hydrochloride holds promise for research in the fields of acute, painful skeletal muscle disorders and infectious diseases.

HY-W701409

rac-Rotigotine methyl ether amide-d₃
rac-Rotigotine methyl ether amide-d₃ is the deuterium labeled rac-Rotigotine methyl ether amide.

HY-B1161S

Methoprene-d₇
Methoprene-d₇ is the deuterium labeled Methoprene. Methoprene, an insect juvenile growth hormone mimic, is a growth-regulating insecticide that manifests its toxicity to target organisms by acting as a juvenile hormone agonist.

HY-78131S1

Ibuprofen-¹³C,d₃
Ibuprofen-¹³C,d₃ is the ¹³C- and deuterium labeled Ibuprofen. Ibuprofen is an anti-inflammatory agent targeting COX-1 and COX-2 with IC50s of 13 μM and 370 μM, respectively.

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