2. Signaling Pathways
  3. Others
  4. Isotope-Labeled Compounds

Isotope-Labeled Compounds

Isotope-labeled compounds are chemical substances in which some atoms in their molecules are replaced by isotope atoms. The range of stable isotope products can cover from gases to complex molecules. Isotope-labeled compounds could provide a site-specific investigation of structures, making molecules easily detectable by mass spectrometry and NMR, and maintaining the physico-chemical properties of the target molecule at the same time. MCE isotope-labeled compounds are all stable isotope-labeled compounds and are non-radioactive labeled substances. MCE isotope-labeled compounds are unique tools for identifying and understanding biological and chemical processes. Stable isotope-labeled products are now getting more and more popular among scientists. The scope of application is gradually penetrating into various scientific fields, such as life sciences, food and medicine, agriculture, environment, geology, etc. Stable isotope-labeled compounds have a wide range of applications in the Life Science areas, such as Metabolomics, Proteomics, Clinical studies, Deuterium drugs, etc.

Isotope-Labeled Compounds Related Products (10876):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N0112S
    Dihydromyricetin-d4
    Dihydromyricetin-d4 (Ampelopsin-d4) is deuterium labeled Dihydromyricetin. Dihydromyricetin is a potent inhibitor with an IC50 of 48 μM on dihydropyrimidinase. Dihydromyricetin can activate autophagy through inhibiting mTOR signaling. Dihydromyricetin suppresses the formation of mTOR complexes (mTORC1/2). Dihydromyricetin is also a potent influenza RNA-dependent RNA polymerase inhibitor with an IC50 of 22 μM.
    Dihydromyricetin-d<sub>4</sub>
  • HY-B0158S8
    Cytidine-d13
    Cytidine-d13 (Cytosine β-D-riboside-d13) is deuterium labeled Cytidine (HY-B0158). Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catecholamine synthesis, and mitochondrial function.
    Cytidine-d<sub>13</sub>
  • HY-N0121S
    Sesamin-d8
    Sesamin-d8 is the deuterium labeled Sesamin (HY-N0121). Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia.
    Sesamin-d<sub>8</sub>
  • HY-127035S1
    Tristearin-13C3
    Tristearin-13C3 (Glycerol tristearate-13C3) is 13C labeled Tristearin. Tristearin is a triglyceride derived from three units of stearic acid.
    Tristearin-13C3
  • HY-17605S1
    Bictegravir-d5
    Bictegravir-d5 is deuterated labeled Bictegravir (HY-17605). Bictegravir (GS-9883) is a potent inhibitor of HIV-1 integrase with an IC50 of 7.5 nM.
    Bictegravir-d<sub>5</sub>
  • HY-112581S
    5-Methoxyuridine-d3
    5-Methoxyuridine-d3 is the deuterium labeled 5-Methoxyuridine (HY-112581). 5-Methoxyuridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-Methoxyuridine-d<sub>3</sub>
  • HY-P11527S
    AALQEELQLC-(Lys-13C6,15N2) TFA
    AALQEELQLC-(Lys-13C6,15N2) TFA is the 13C- and 15N-labeled AALQEELQLC.
    AALQEELQLC-(Lys-<sup>13</sup>C<sub>6</sub>,<sup>15</sup>N<sub>2</sub>) TFA
  • HY-132432S
    N10-Monodesmethyl Rizatriptan-d3
    N10-Monodesmethyl Rizatriptan-d3 is the deuterium labeled N10-Monodesmethyl Rizatriptan.
    N10-Monodesmethyl Rizatriptan-d<sub>3</sub>
  • HY-W744953
    Carbimazole-d3
    Carbimazole-d3 is deuterium labeled Carbimazole. Carbimazole is an orally active antithyroid agent which rapidly converts to Methimazole after absorption and prevents thyroid peroxidase enzyme from iodinating and coupling the tyrosine residues on thyroglobulin, hence reducing the production of thyroxine. Carbimazole also displays anti-inflammatory and neuronal-protective activities, suggesting its application for hyperthyroidism and neurological research.
    Carbimazole-d<sub>3</sub>
  • HY-167593S
    C18:0-d7 GM1 Ceramide
    C18:0-d7 GM1 Ceramide is deuterium labeled C18:0 GM1 Ceramide.
    C18:0-d<sub>7</sub> GM1 Ceramide
  • HY-N2041S8
    Myristic acid-13C2
    Myristic acid-13C2 is the 13C-labeled Myristic acid (HY-N2041). Myristic acid is an orally active saturated 14-carbon fatty acid found in most animal and plant fats, especially milk fat coconut oil, palm oil and nutmeg oil. Myristic acid exerts anti-inflammatory activity through the NF-κB pathway. Myristic acid has antibacterial, anti-inflammatory and analgesic properties.
    Myristic acid-<sup>13</sup>C<sub>2</sub>
  • HY-14649S2
    11-cis-Retinoic Acid-d5
    11-cis-Retinoic Acid-d5 is the deuterium labeled Retinoic acid. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[1][2].
    11-cis-Retinoic Acid-d<sub>5</sub>
  • HY-W703863S
    Pyrimidifen-d4
    Pyrimidifen-d4 is the deuterium labeled Pyrimidifen (HY-W703863). Pyrimidifen is a phenoxyethyl amine compound and is an acaricide. Pyrimidifen controls the African red mite, Eutetranychus africanus with a persistency of 14-21 days.
    Pyrimidifen-d<sub>4</sub>
  • HY-B0256S
    Azathioprine-d3
    Azathioprine-d3 (BW 57-322-d3) is the deuterium labeled Azathioprine (HY-B0256). Azathioprine (BW 57-322) is an orally active immunosuppressive agent. Azathioprine can be converted in vivo to the active metabolite 6-mercaptopurine (6-MP). Azathioprine has myelosuppressive effects and induces apoptosis.
    Azathioprine-d<sub>3</sub>
  • HY-B0114S
    Oxcarbazepine-d4
    Oxcarbazepine-d4 (GP 47680-D4) is the deuterium labeled Oxcarbazepine. Oxcarbazepine is a sodium channel blocker. Oxcarbazepine significantly inhibits glioblastoma cell growth and induces apoptosis or G2/M arrest in glioblastoma cell lines. Anti-cancer and anticonvulsant effects.
    Oxcarbazepine-d<sub>4</sub>
  • HY-122129S
    Dotriaconta-14,17,20,23,26,29-hexaenoic acid-d6
    Dotriaconta-14,17,20,23,26,29-hexaenoic acid-d6 is deuterium labeled Dotriaconta-14,17,20,23,26,29-hexaenoic acid. Very long chain polyunsaturated fatty acids (VLCPUFA) are present in retina, sperm, and brain. Though little is known of their biosynthesis or functional roles in these tissues, recent studies using the elongation of very long-chain FA-4 protein suggest a unique role for VLCPUFA in retinal development and macular degeneration. Dotriaconta-14,17,20,23,26,29-hexaenoic acid is a C32:6 VLCPUFA whose specific biological actions are largely unknown, but are thought to involve normal photoreceptor cell function in the retina.
    Dotriaconta-14,17,20,23,26,29-hexaenoic acid-d<sub>6</sub>
  • HY-N0830S22
    Palmitic acid-13C-1
    Palmitic acid-13C-1 is the 13C-labeled Palmitic acid (HY-N0830). Palmitic acid is a long-chain saturated fatty acid commonly found in both animals and plants. PA can induce the expression of glucose-regulated protein 78 (GRP78) and CCAAT/enhancer binding protein homologous protein (CHOP) in in mouse granulosa cells. Palmitic acid is used to establish a cell steatosis model.
    Palmitic acid-<sup>13</sup>C-1
  • HY-16746S
    Lavamilast-d8 hydrochloride
    Lavamilast-d8 (hydrochloride) is deuterium-labeled Lavamilast (HY-16746).
    Lavamilast-d<sub>8</sub> hydrochloride
  • HY-W748319
    K 101-13C12
    K 101-13C12 is 13C labeled K 101.
    K 101-<sup>13</sup>C<sub>12</sub>
  • HY-W748322
    1,​2,​3,​4,​7,​8-​Hexachloro-dibenzofuran-​13C12
    1, 2, 3, 4, 7, 8- Hexachloro-dibenzofuran- 13C12 is 13C labeled 1,2,3,4,7,8-Hexachlorodibenzofuran.
    1,​2,​3,​4,​7,​8-​Hexachloro-dibenzofuran-​<sup>13</sup>C<sub>12</sub>