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Cat. No.: HY-112581S

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5-Methoxyuridine-d₃

5-Methoxyuridine-d₃ is the deuterated-labeled 5-Methoxyuridine (HY-112581). 5-Methoxyuridine is a purine nucleoside analog. 5-Methoxyuridine is present in bacterial tRNA and acts as an innate immune suppressor and protein translation inducer.

For research use only. We do not sell to patients.

Formula: C₁₀H₁₁D₃N₂O₇
Molecular Weight:277.25

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (284 KB)

5-Methoxyuridine-d₃ Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
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Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled CAS 35542-01-9
Molecular Weight 277.25
Formula C₁₀H₁₁D₃N₂O₇
SMILES

OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(C(OC([2H])([2H])[2H])=C2)=O)=O)O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (284 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Miles JR, et al. Sub-stoichiometric 5-methoxyuridine modification enables tunable immune evasion and protein expression from synthetic mRNAs. Molecular therapy. Nucleic acids. 2026 Sep 08;37(3):103058.

[2]. Holland R, et al. Silicon Ether Ionizable Lipids Enable Potent mRNA Lipid Nanoparticles with Rapid Tissue Clearance. ACS nano. 2024 Apr 16;18(15):10374-10387.

[3]. Ryu H, et al. Identification of a novel tRNA wobble uridine modifying activity in the biosynthesis of 5-methoxyuridine. Nucleic acids research. 2018 Sep 28;46(17):9160-9169.

[4]. Murao K, et al. 5-methoxyuridine: a new minor constituent located in the first position of the anticodon of tRNAAla, tRNAThr, and tRNAVal from Bacillus subtilis. Nucleic acids research. 1976 Oct;3(10):2851-60.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
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5-Methoxyuridine-d3

Biological Activity

Description

Application

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

5-Methoxyuridine-d3 Related Classifications

HY-112581S Related Classifications

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