35542-01-9
35542-01-9
Chemical Structure
5-Methoxyuridine
- CAS No.: 35542-01-9
- Formula:C10H14N2O7
- Molecular Weight:274.23
IUPAC Name: 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methoxypyrimidine-2,4(1H,3H)-dione
InChIKey: ZXIATBNUWJBBGT-JXOAFFINSA-N
SMILES: OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC(C(OC)=C2)=O)=O)O1
Biological Activity: 5-Methoxyuridine is a purine nucleoside analog. 5-Methoxyuridine is present in bacterial tRNA and acts as an innate immune suppressor and protein translation inducer[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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5-Methoxyuridine | 99.98% | 5-Methoxyuridine is a purine nucleoside analog. 5-Methoxyuridine is present in bacterial tRNA and acts as an innate immune suppressor and protein translation inducer. | ||||||||||||||||||||
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5-Methoxyuridine-d3 | 5-Methoxyuridine-d3 is the deuterated-labeled 5-Methoxyuridine (HY-112581). 5-Methoxyuridine is a purine nucleoside analog. 5-Methoxyuridine is present in bacterial tRNA and acts as an innate immune suppressor and protein translation inducer. | |||||||||||||||||||||
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References
- [1]. Miles JR, et al. Sub-stoichiometric 5-methoxyuridine modification enables tunable immune evasion and protein expression from synthetic mRNAs. Molecular therapy. Nucleic acids. 2026 Sep 08;37(3):103058.
- [2]. Holland R, et al. Silicon Ether Ionizable Lipids Enable Potent mRNA Lipid Nanoparticles with Rapid Tissue Clearance. ACS nano. 2024 Apr 16;18(15):10374-10387.
- [3]. Ryu H, et al. Identification of a novel tRNA wobble uridine modifying activity in the biosynthesis of 5-methoxyuridine. Nucleic acids research. 2018 Sep 28;46(17):9160-9169.
- [4]. Murao K, et al. 5-methoxyuridine: a new minor constituent located in the first position of the anticodon of tRNAAla, tRNAThr, and tRNAVal from Bacillus subtilis. Nucleic acids research. 1976 Oct;3(10):2851-60.
