2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Phosphoglycerate Dehydrogenase (PHGDH)
  5. Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor

Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor

Phosphoglycerate Dehydrogenase (PHGDH) Inhibitors (5):

Cat. No. Product Name Effect Purity
  • HY-161456
    PHGDH-IN-5
    		Inhibitor
    PHGDH-IN-5 (Compound B12) is a covalen inhibitor of PHGDH with an IC50 value of 0.29 μM. PHGDH-IN-5 can inhibit cell proliferation in cancer cell lines overexpressing PHGDH. PHGDH-IN-5 can reduce the production of serine derived from glucose in MDA-MB-468 cells.
  • HY-123269
    PKUMDL-WQ-2101
    		Inhibitor 99.85%
    PKUMDL-WQ-2101 is a non-NAD+-competing allosteric phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 34.8 μM. PKUMDL-WQ-2101 exhibits antitumor activity.
  • HY-148570
    PHGDH-IN-3
    		Inhibitor 98.99%
    PHGDH-IN-3 is an orally active phosphoglycerate dehydrogenase (PHGDH) inhibitor. PHGDH-IN-3 inhibits PHGDH with an IC50 value of 2.8 μM. PHGDH-IN-3 can be used for the research of cancer.
  • HY-123418
    PKUMDL-WQ-2201
    		Inhibitor 98.72%
    PKUMDL-WQ-2201 is a PHGDH non-NAD+-competing allosteric inhibitor (IC50=35.7 μM). PKUMDL-WQ-2201 also inhibits PHGDH mutants with IC50s of 69 μM (T59A) and >300 μM (T56AK57A), respectively. PKUMDL-WQ-2201 inhibits de novo serine synthesis in cancer cells, and reduces tumor growth.
  • HY-160252
    PHGDH-IN-4
    		Inhibitor
    PHGDH-IN-4 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor. PHGDH-IN-4 can be used for the research of cancer.