PHGDH-IN-6
PHGDH-IN-6 is a phosphoglycerate dehydrogenase (PHGDH) inhibitor with an IC50 of 2.5 μM. PHGDH-IN-6 binds to the allosteric pocket of PHGDH, and its inhibitory activity is not affected by NAD+ concentration. PHGDH-IN-6 can be used in research related to cancer and Alzheimer's disease.
For research use only. We do not sell to patients.
- Formula: C33H28BrN3O8
- Molecular Weight:674.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
PHGDH-IN-6 (compound L5) (0.1-100 μM) potently inhibits recombinant PHGDH enzymatic activity with an IC50 of 2.5 μM via binding to an allosteric pocket[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 674.49
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Formula C33H28BrN3O8
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SMILES
BrC1=CC(C#CC2=CC=C(NC(C3=C(NC([C@]45C[C@H](NC(OC(C)(C)C)=O)C(O5)=O)=O)C4=CC=C3)=O)C=C2)=CC(C(OC)=O)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PHGDH-IN-6 Related Classifications
HY-179652 Related Classifications
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