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Cat. No.: HY-179652

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PHGDH-IN-6

PHGDH-IN-6 (Compound L5) is a PHGDH allosteric inhibitor with an IC₅₀ of 2.5 μM. PHGDH-IN-6 can be used for studying diseases related to serine synthesis.

For research use only. We do not sell to patients.

Formula: C₃₃H₂₈BrN₃O₈
Molecular Weight:674.49

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

PHGDH-IN-6 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

PHGDH-IN-6 (Compound L5) is a PHGDH allosteric inhibitor with an IC₅₀ of 2.5 μM. PHGDH-IN-6 can be used for studying diseases related to serine synthesis^[1].

Chemical Information

Molecular Weight 674.49
Formula C₃₃H₂₈BrN₃O₈
SMILES

BrC1=CC(C#CC2=CC=C(NC(C3=C(NC([C@]45C[C@H](NC(OC(C)(C)C)=O)C(O5)=O)=O)C4=CC=C3)=O)C=C2)=CC(C(OC)=O)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang Y, et al. Biocatalytic- and Chemoproteomic-Guided Discovery of a PHGDH Inhibitor from Chemoenzymatic-Promoted DNA-Encoded Libraries Selection Platform. J Am Chem Soc. 2025 Dec 3;147(48):44396-44405. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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