Phosphorylase

Phosphorylase is an enzyme that catalyzes the addition of a phosphate group from an inorganic phosphate (phosphate+hydrogen) to an acceptor, including glycogen phosphorylase, starch phosphorylase, nucleoside diphosphate kinase, etc. Phosphorylase participates in cell signal transduction and activates signal pathways through phosphorylation. Phosphorylase plays a crucial role in metabolic processes and is extensively involved in the metabolic regulation of substances such as sugars, nucleotides, and lipids. Phosphorylase can also regulate cell differentiation, proliferation, apoptosis, and gene expression, affecting the fate and function of cells. Abnormal activity or expression of phosphorylase leads to metabolic diseases such as glycogen storage disease, and is also closely related to the occurrence and development of cancer, neurodegenerative diseases, etc^[1].

References:

[1]. Watson KA, et al. Phosphorylase recognition and phosphorolysis of its oligosaccharide substrate: answers to a long outstanding question. EMBO J. 1999 Sep 1;18(17):4619-32. [Content Brief]

Phosphorylase Related Products (23):

By Effects:	Inhibitors (18) Control (1) Substrates (2)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-B1467R

Domiphen bromide (Standard)	Inhibitor
Domiphen bromide (Standard) is the analytical standard of Domiphen bromide (HY-B1467). This product is intended for research and analytical applications. Domiphen bromide is a cationic active quaternary ammonium salt and also an inhibitor of HERG channels (IC₅₀: 9 nM), aminopeptidase-like enzymes, Escherichia coli alkaline phosphatase, and α-chymotrypsin. Domiphen bromide has multiple activities such as antibacterial, antimalarial, and disinfectant properties, and it is also a synergist of Colistin (HY-113678). Domiphen bromide can be used as a chemical preservative and a cationic surfactant, and it can also be used in the research of bacterial infectious diseases such as pharyngitis, thrush, and oral ulcers.

HY-171451

RMGPa-IN-1	Inhibitor
RMGPa-IN-1 (Compound 10C) is a rabbit muscle glycogen phosphorylase a (RMGPa) inhibitor with an IC₅₀ value of 82.5 μM. RMGPa-IN-1 is promising for research of diabetes.

HY-136508

8-Aminoguanosine	Inhibitor
8-Aminoguanosine is a purine nucleoside phosphorylase inhibitor. 8-Aminoguanosine blocks purine nucleoside phosphorylation via specific binding.

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