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Cat. No.: HY-136508

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8-Aminoguanosine

8-Aminoguanosine is a purine nucleoside phosphorylase inhibitor. 8-Aminoguanosine blocks purine nucleoside phosphorylation via specific binding.

For research use only. We do not sell to patients.

CAS No.: 3868-32-4
Formula: C₁₀H₁₄N₆O₅
Molecular Weight:298.26

Storage:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

8-Aminoguanosine Chemical Structure

CAS No.: 3868-32-4

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

8-Aminoguanosine is a purine nucleoside phosphorylase inhibitor. 8-Aminoguanosine blocks purine nucleoside phosphorylation via specific binding^[1].

All DNA/RNA Synthesis Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MOLT-4	IC₅₀	~500 μM Compound: 1b	Cytotoxicity was evaluated against human MOLT-4 T-lymphoblasts (absence of 10 uM 2'-deoxyguanosine (Wo/GdR)) Cytotoxicity was evaluated against human MOLT-4 T-lymphoblasts (absence of 10 uM 2'-deoxyguanosine (Wo/GdR))	[PMID: 3091835]
MOLT-4	IC₅₀	3.25 μM Compound: 1a	Cytotoxic effect on the growth of human T-and B-lymphoblastoid cell lines(MOLT-4 and MGL-8) evaluated by measuring inhibition of thymidine intake in presence of 10 uM deoxyguanosine Cytotoxic effect on the growth of human T-and B-lymphoblastoid cell lines(MOLT-4 and MGL-8) evaluated by measuring inhibition of thymidine intake in presence of 10 uM deoxyguanosine	[PMID: 1573639]
MOLT-4	IC₅₀	3.25 μM Compound: 1b	Cytotoxicity was evaluated against human MOLT-4 T-lymphoblasts (presence of 10 uM 2'-deoxyguanosine (W/GdR)) Cytotoxicity was evaluated against human MOLT-4 T-lymphoblasts (presence of 10 uM 2'-deoxyguanosine (W/GdR))	[PMID: 3091835]

In Vitro

8-Aminoguanosine (25-100 μM) does not inhibit adenosine phosphorylation by enzyme extracts from Toxoplasma gondii, human liver, or mouse liver^[1].
8-Aminoguanosine (25-100 μM) does not inhibit NBMPR phosphorylation by enzyme extracts from Toxoplasma gondii^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3868-32-4
Appearance Solid
Molecular Weight 298.26
Formula C₁₀H₁₄N₆O₅
SMILES

OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(N)=NC3=C2NC(N)=NC3=O)O1
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. el Kouni MH, et al. Metabolism and selective toxicity of 6-nitrobenzylthioinosine in Toxoplasma gondii. Antimicrob Agents Chemother. 1999;43(10):2437-2443. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Chemical Information
Purity & Documentation
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8-Aminoguanosine

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

8-Aminoguanosine Related Classifications

HY-136508 Related Classifications