2. Signaling Pathways
  3. PI3K/Akt/mTOR
  4. PIN1

PIN1

peptidylprolyl cis/trans isomerase, NIMA-interacting 1

PIN1 is a peptidyl-prolyl isomerase (PPIase) that specifically recognizes the pSer/Thr-Pro motif, catalyzes the cis and trans isomerization of the proline amide bond, changes the conformation of the substrate protein, thereby affecting its function, stability or intracellular localization. PIN1 regulates cell cycle proteins such as cyclin D, cyclin E, and CDC25, thereby regulating the G1-S process and mitotic progression. PIN1 regulates the stability of proteins such as p53 and p73, responds to stress signals such as DNA damage, and thus affects cell cycle arrest or apoptosis. PIN1 regulates the phosphorylation of tau protein, mediating the neurological functions. PIN1 regulates transcription factors such as NF-κB and JUN, mediates immune responses. PIN1 dysfunction could lead to Alzheimer's disease, cancer, asthma, or microbial infection[1][2].

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-168036
    PIN1 inhibitor 3
    		Inhibitor
    PIN1 inhibitor 3 (Compound A0) is a PIN1 inhibitor, with a KD of 25 nM and an IC50 of 150 nM. PIN1 inhibitor 3 can be used as a target protein ligand for the synthesis of PROTAC. PIN1 inhibitor 3 can be utilized in cancer research.
    PIN1 inhibitor 3
  • HY-171442A
    (R)-PIN1 ligand-2
    (R)-PIN1 ligand-2 is a PIN1 ligand, and can be used for synthesis of PROTACs, such as P1D-34 (HY-171334A).
    (R)-PIN1 ligand-2
  • HY-168872
    API32
    		Inhibitor
    API32 is a potent Pin1 inhibitor. API32 interactes with the Pin1 PPIase domain. API32 inhibits cell proliferation and migration. API32 has the potential for the research of hepatocellular carcinoma (HCC).
    API32
  • HY-170429
    BJP-07-017-3
    		Inhibitor
    BJP-07-017-3 is the inhibitor for proline cis trans isomerase (Pin1) with an IC50 of 9 nM. BJP-07-017-3 forms covalent bond with Cys113 of Pin1, induces conformational changes in Pin1, reduces its stability, and leads to a proteasome-dependently degradation.
    BJP-07-017-3
  • HY-12135
    Poloxipan
    		Inhibitor
    Poloxipan is a pan-specific polo-like kinase (PLK) inhibitor that can inhibit a non-catalytic region at the C-terminus called the Polo-box domain (PBD) found in kinases. The IC50 values for Poloxipan against the PBDs of PLK-1/2/3 are 3.2 μM, 1.7 μM, and 3.0 μM, respectively. Poloxipan also inhibits other phospho-tyrosine binding domains, such as the forkhead-associated (FHA) domain of CHK-2, the WW domain of peptidyl-prolyl cis/trans isomerase (PIN1), and the phospho-tyrosine binding domains of STAT1/3/5 and lymphocyte-specific protein tyrosine kinase's SH2 domain. Poloxipan can be used in cancer research.
    Poloxipan
  • HY-N19860
    L-Balenine
    		Inhibitor
    L-Balenine is an orally active Pin1 inhibitor and intracellular pH buffer. L-Balenine enhances the phagocytic activity of macrophages, and promotes the expression of pro-inflammatory and anti-inflammatory cytokines during muscle degeneration. L-Balenine also upregulates the expression of myogenic marker genes associated with regeneration, thereby effectively driving skeletal muscle regeneration. L-Balenine can be widely used in studies related to skeletal muscle injury and its repair mechanisms.
    L-Balenine
  • HY-129310
    PIN1 inhibitor 5
    		Inhibitor
    PIN1 inhibitor 5 (compound 7) is a PIN1 inhibitor (Ki=0.08 μM) ,which can be used in cancer research.
    PIN1 inhibitor 5
  • HY-W843265
    PIN1 inhibitor 6
    		Inhibitor
    PIN1 inhibitor 6 (compound 38) is a Pin1 inhibitor. PIN1 inhibitor 6 can be utilized in cancer research.
    PIN1 inhibitor 6
Cat. No. Product Name / Synonyms Application Reactivity