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Cat. No.: HY-168036

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PIN1 inhibitor 3

PIN1 inhibitor 3 (Compound A0) is a PIN1 inhibitor, with a K_D of 25 nM and an IC₅₀ of 150 nM. PIN1 inhibitor 3 can be used as a target protein ligand for the synthesis of PROTAC. PIN1 inhibitor 3 can be utilized in cancer research.

For research use only. We do not sell to patients.

CAS No.: 3039570-04-9
Formula: C₃₅H₃₇N₇O₂
Molecular Weight:587.71

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

PIN1 inhibitor 3 Chemical Structure

CAS No.: 3039570-04-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

IC50: 150 nM (PIN1)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	GI₅₀	9.9 μM Compound: C10	Antiproliferative activity against human Huh-7 cells assessed as cell growth inhibition incubated for 96 hrs by Cell-Titer Glo assay Antiproliferative activity against human Huh-7 cells assessed as cell growth inhibition incubated for 96 hrs by Cell-Titer Glo assay	[PMID: 39229909]
MDA-MB-468	GI₅₀	36.8 μM Compound: C10	Antiproliferative activity against human MDA-MB-468 cells assessed as cell growth inhibition incubated for 96 hrs by Cell-Titer Glo assay Antiproliferative activity against human MDA-MB-468 cells assessed as cell growth inhibition incubated for 96 hrs by Cell-Titer Glo assay	[PMID: 39229909]
PANC-1	GI₅₀	9.3 μM Compound: C10	Antiproliferative activity against human PANC-1 cells assessed as cell growth inhibition incubated for 96 hrs by Cell-Titer Glo assay Antiproliferative activity against human PANC-1 cells assessed as cell growth inhibition incubated for 96 hrs by Cell-Titer Glo assay	[PMID: 39229909]

Chemical Information

CAS No. 3039570-04-9
Molecular Weight 587.71
Formula C₃₅H₃₇N₇O₂
SMILES

CC1=CC=CC=C1C2(CC2)C(NC(C(NC(CC3)CCN3C)=O)CC(N=N4)=CN4C(C=C5)=CC=C5C(C=C6)=CC=C6C#N)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Liu C, et al. Re-Evaluating PIN1 as a Therapeutic Target in Oncology Using Neutral Inhibitors and PROTACs. J Med Chem. 2024 Sep 12;67(17):15780-15795. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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