PIN1 inhibitor 3
PIN1 inhibitor 3 (Compound A0) is a PIN1 inhibitor, with a KD of 25 nM and an IC50 of 150 nM. PIN1 inhibitor 3 can be used as a target protein ligand for the synthesis of PROTAC. PIN1 inhibitor 3 can be utilized in cancer research.
For research use only. We do not sell to patients.
- CAS No.: 3039570-04-9
- Formula: C35H37N7O2
- Molecular Weight:587.71
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
IC50: 150 nM (PIN1)[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | GI50 |
9.9 μM
Compound: C10
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Antiproliferative activity against human Huh-7 cells assessed as cell growth inhibition incubated for 96 hrs by Cell-Titer Glo assay
Antiproliferative activity against human Huh-7 cells assessed as cell growth inhibition incubated for 96 hrs by Cell-Titer Glo assay
|
[PMID: 39229909] |
| MDA-MB-468 | GI50 |
36.8 μM
Compound: C10
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Antiproliferative activity against human MDA-MB-468 cells assessed as cell growth inhibition incubated for 96 hrs by Cell-Titer Glo assay
Antiproliferative activity against human MDA-MB-468 cells assessed as cell growth inhibition incubated for 96 hrs by Cell-Titer Glo assay
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[PMID: 39229909] |
| PANC-1 | GI50 |
9.3 μM
Compound: C10
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Antiproliferative activity against human PANC-1 cells assessed as cell growth inhibition incubated for 96 hrs by Cell-Titer Glo assay
Antiproliferative activity against human PANC-1 cells assessed as cell growth inhibition incubated for 96 hrs by Cell-Titer Glo assay
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[PMID: 39229909] |
Chemical Information
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CAS No. 3039570-04-9
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Molecular Weight 587.71
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Formula C35H37N7O2
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SMILES
CC1=CC=CC=C1C2(CC2)C(NC(C(NC(CC3)CCN3C)=O)CC(N=N4)=CN4C(C=C5)=CC=C5C(C=C6)=CC=C6C#N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PIN1 inhibitor 3 Related Classifications
HY-168036 Related Classifications
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