Steroid Sulfatase

Steroid sulfatase (STS) is a glycosylated protein with an apparent molecular weight of about 63–73 kDa. STS catalyzes the hydrolysis of the sulfate esters of 3-hydroxy steroids, which are inactive transport or precursor forms of the active 3-hydroxy steroids. STS can cleave estrone sulfate (E1S) and DHEA sulfate (DHEAS). STS is a potential target for the treatment of hormone-dependent diseases^[1].

References:

[1]. M J Reed, et al. Steroid sulfatase: molecular biology, regulation, and inhibition. Endocr Rev. 2005 Apr;26(2):171-202. [Content Brief]

Steroid Sulfatase Related Products (26):

By Effects:	Inhibitors (23) Agonist (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-155233

Steroid sulfatase-IN-5	Inhibitor
Steroid sulfatase-IN-5 (compound 10b) is a steroid sulfatase (STS) inhibitor (IC₅₀: 0.32 nM). Steroid sulfatase-IN-5 inhibits T-47D cell proliferation with an IC₅₀ of 35.7 μM. Steroid sulfatase-IN-5 can be used for research of breast cancer.

HY-151199

Steroid sulfatase/17β-HSD1-IN-1	Inhibitor
Steroid sulfatase/17β-HSD1-IN-1 is a potent steroid sulfatase and 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) inhibitor with an IC₅₀ value of 28 nM for cellular human steroid sulfatase. Steroid sulfatase/17β-HSD1-IN-1 can be used to research estrogen-dependent diseases.

HY-174987

mGluR1 activator-1	Agonist
mGluR1 activator-1 is a stable Vitamin K (HY-B2172) analogue and a mGluR1 activator that can penetrate the blood-brain barrier. mGluR1 activator-1 exhibits strong transcriptional activation via steroid and xenobiotic receptor as well as retinoic acid receptor. mGluR1 activator-1 induces neuronal differentiation in mouse neural progenitor cells. mGluR1 activator-1 can be used for the study of neurodegenerative disease such as Alzheimer’s.

HY-151202

Steroid sulfatase/17β-HSD1-IN-4	Inhibitor
Steroid sulfatase/17β-HSD1-IN-4 (compound 37) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β HSD1). Steroid sulfatase/17β-HSD1-IN-4 irreversibly inhibits hSTS activity with anIC₅₀ value of 63 nM. Steroid sulfatase/17β-HSD1-IN-4 can be used in the study of endometriosis and other estrogen-dependent diseases.

HY-123420

Dinordrin
Dinordrin (Dinordrin I) is a steroid with a luteolytic effect. Dinordrin can cause depression of both plasma estrogen and progesterone levels.

HY-181408

Steroid sulfatase-IN-11	Inhibitor
Steroid sulfatase-IN-11 is a steroid sulfatase inhibitor, which functionally inhibits steroid sulfatase activity, reducing the enzyme's ability to hydrolyze steroid sulfates. Steroid sulfatase-IN-11 can be used for the research of hormone-dependent cancers.

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