mGluR1 activator-1
mGluR1 activator-1 is a stable Vitamin K (HY-B2172) analogue and a mGluR1 activator that can penetrate the blood-brain barrier. mGluR1 activator-1 exhibits strong transcriptional activation via steroid and xenobiotic receptor as well as retinoic acid receptor. mGluR1 activator-1 induces neuronal differentiation in mouse neural progenitor cells. mGluR1 activator-1 can be used for the study of neurodegenerative disease such as Alzheimer’s.
For research use only. We do not sell to patients.
- Formula: C27H30O4
- Molecular Weight:418.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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mGluR1 |
mGluR1 activator-1 (Compound 7) (1-10 μM, 48 h) regulates transcriptional activity via SXR and RAR in neural stem cells[1].
mGluR1 activator-1 (1 μM, 48 h) significantly increases the positive signal of Map2, indicating that it can effectively induce neural progenitor cells to differentiate into neurons[1].
mGluR1 activator-1 (1-10 μM, 24 h) shows a concentration-dependent increase in cellular uptake in MG63 cells, and can be converted by the cells into a bioactive form Menaquinone-4 (MK-4) (HY-B2156)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Neural progenitor cellsneural progenitor cells
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Concentration:1 μM
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Incubation Time:48 h
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Result:Observed a significant increase in Map2 mRNA expression.
Chemical Information
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Molecular Weight 418.52
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Formula C27H30O4
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SMILES
O=C(/C(C)=C/C=C/C(C)=C/CC/C(C)=C/CC1=C(C(C2=C(C1=O)C=CC=C2)=O)C)OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
mGluR1 activator-1 Related Classifications
HY-174987 Related Classifications
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