Steroid sulfatase-IN-11 

Steroid sulfatase-IN-11 is a steroid sulfatase inhibitor, which functionally inhibits steroid sulfatase activity, reducing the enzyme's ability to hydrolyze steroid sulfates. Steroid sulfatase-IN-11 can be used for the research of hormone-dependent cancers^[1].

Steroid sulfatase-IN-11 (compound 9j) (0.1-10 μM) potently inhibits isolated human placental STS, reducing residual activity to 31.2%, 7.9% and 4.6% at concentrations of 0.1 μM, 1 μM and 10 μM, respectively^[1].
Steroid sulfatase-IN-11 (0.1-10 μM) potently inhibits STS activity in JEG-3 cells, with an IC₅₀ value of 6.64 nM; it reduces the residual activity to 10.8% at a concentration of 0.1 μM, to 0.9% at 1 μM, and achieves complete inhibition at 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

353.30

C₁₄H₉F₂N₃O₄S

3075596-38-9

O=S(OC1=CC=C(C2=NOC(C3=CC(F)=CC(F)=C3)=N2)C=C1)(N)=O

Room temperature in continental US; may vary elsewhere.

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• [1]. Biernacki K, et al. Synthesis and Biological Evaluation of 3,5-Diaryl-Substituted 1,2,4-Oxadiazole Sulfamates as Potent Steroid Sulfatase Inhibitors. ACS Med Chem Lett. 2026;17(2):510-519. Published 2026 Jan 16.  [Content Brief]