Transmembrane Glycoprotein

Transmembrane glycoproteins are important components of cell membranes and are characterized by oligosaccharide chains covalently linked to polypeptide chains. Glycosylation sites are mainly located in their extracellular regions, achieved by N-linked glycosylation (linked to asparagine residues) or O-linked glycosylation (linked to serine or threonine residues). Sugar chains not only provide structural stability to proteins but also confer functional specificity. Many transmembrane glycoproteins are receptors, such as G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs). Most （clusters of differentiation）CD molecules are also transmembrane glycoproteins expressed on the surface of antigen-presenting cells^[1]^[2].

References:

[1]. L Franco, et al. The transmembrane glycoprotein CD38 is a catalytically active transporter responsible for generation and influx of the second messenger cyclic ADP-ribose across membranes. FASEB J. 1998 Nov;12(14):1507-20. [Content Brief]

[2]. Kumi Oshima, et al. SHPS-1, a multifunctional transmembrane glycoprotein. FEBS Lett. 2002 May 22;519(1-3):1-7. [Content Brief]

Transmembrane Glycoprotein Related Products (368):

By Effects:	Inhibitors (229) Agonists (7) Ligands (14) Antagonists (7) Activators (10) Modulators (5)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-P992422

NG004	Inhibitor
NG004 is a fully human monoclonal antibody targeting Nogo-A. NG004 reduces retinal Nogo-A levels, blocks the binding of the Nogo-A-receptor complex, and neutralizes the Nogo-A protein. NG004 can be used in studies related to diabetic retinopathy, stroke and acute spinal cord injury.

HY-P991475

MG-1131	Inhibitor
MG-1131 is a human monoclonal antibody (mAb) targeting TIGIT. MG-1131 activates NF-κB signaling in T cells and enhances NK-mediated tumor killing activity in a PVR-dependent manner. MG-1131 blocks TIGIT to increase IFN-γ secretion. MG-1131 can be used in anti-tumor immunity research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).

HY-179606

RWT9996	Antagonist
RWT9996 is a balanced GPR17 antagonist. RWT9996 has an inhibitory effect on G protein activation and β-arrestin-2 recruitment induced by MDL-29951. RWT9996 inhibits the phosphorylation of ERK/CREB and the accumulation of inositol phosphate (b IP1) induced by MDL-29951. RWT9996 can be used for the study of neurological diseases.

HY-P992277

Anti-NKp46 Antibody
Anti-NKp46 Antibody is a monoclonal antibody targeting NKp46. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-NKp46 Antibody, please refer to Mouse IgG1 kappa, Isotype Control (HY-P99977).

HY-B0640AR

Epinastine hydrochloride (Standard)	Inhibitor
Epinastine (hydrochloride) (Standard) is the analytical standard of Epinastine hydrochloride (HY-B0640A). This product is intended for research and analytical applications. Epinastine hydrochloride (WAL801 hydrochloride) is a selective and orally active histamine H1 receptor antagonist, CD96/PVR inhibitor and mast cell stabilizer. Epinastine hydrochloride has high affinity for neuronal octopamine receptors in locusts (K_i = 2 nM) and honeybees (K_i = 1.1 nM). Epinastine hydrochloride inhibits TARC, IL-8, and IL-4. Epinastine hydrochloride activates anti-colon cancer immunity and inhibits Substance P (HY-P0201)-induced scratching behavior and increased vascular permeability. Epinastine hydrochloride can be used in the research of allergic diseases.

HY-P99790

Priliximab
Priliximab (CEN 000029) is an anti-CD4 humanized monoclonal antibody. Priliximab binds to CD4 on the surface of T cells, resulting in a significant and sustained reduction in circulating CD4⁺ T cells. Priliximab can be used in research of rheumatoid arthritis (RA).

HY-P991932

Anti-CD79A Antibody
Anti-CD79A Antibody is an antibody against human CD79a. Recommend Isotype Controls:?Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P5745

TYVPANASL
TYVPANASL is a MHC I-binding CD8 T cell epitope of nine amino acids from HER2/neu. TYVPANASL can be used to prepare J-LEAPS vaccine.

HY-P1796A

Gp100 (619-627) acetate
Gp100 (619-627) acetate is amino acids 619 to 627 fragment of human melanoma antigen glycoprotein 100 (gp100). Gp100 has been a widely studied target for melanoma immunotherapy.

HY-P2696

EP 80317	Ligand
EP 80317 is a selective CD36 ligand. EP 80317 protects the heart against damage and dysfunction elicited by myocardial ischaemia and reperfusion (MI/R), along with a transient reduction in peripheral lipolysis. EP 80317 can be used for the study of cardiovascular disease.

HY-P991188

MGD007	Inhibitor
MGD007 is a humanized IgG1 monoclonal antibody targeting GPA33. MGD007 can be used for study of Metastatic Colorectal Cancer.

HY-P99436

Anatumomab mafenatox	Inhibitor
Anatumomab mafenatox (ABR-214936) is a 73 KDa recombinant protein to recognize the tumor-associated antigen 5T4, which is widely expressing in malignancy. Anatumomab mafenatox is between a modified form of SEA and a murine Fab. The main side effects of Anatumomab mafenatox are reported to include fever, low blood pressure, pain, nausea and drowsiness.

HY-P992213

Anti-CD79 Antibody
Anti-CD79 Antibody is a monoclonal antibody that targets CD79. Anti-CD79 Antibody can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-CD79 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P992217

Anti-CDH19 Antibody
Anti-CDH19 Antibody is a monoclonal antibody that targets CDH19. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-CDH19 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).

HY-125554

KDdiA-PC	Ligand
KDdiA-PC is one of the most potent CD36 ligands in oxidized LDL (oxLDL).

HY-P992194

Anti-BCAM Antibody
Anti-BCAM Antibody is a monoclonal antibody that targets BCAM. It can be used in ELISA, FACS, and functional assays. For isotype controls of Anti-BCAM Antibody, please refer to Human IgG4 (S228P) kappa, Isotype Control (HY-P99003).

HY-P992200

Anti-CD146 Antibody (AA98)	Inhibitor
Anti-CD146 Antibody (AA98) is an antibody targeting CD146 and an angiogenesis inhibitor. Anti-CD146 Antibody (AA98) blocks the dimerization of CD146 as well as its downstream PI3K/AKT, p38 MAPK and NF-κB signaling pathways; it inhibits the expression of MMP9 and ICAM1, epithelial-mesenchymal transition (EMT), and the proliferation, migration and tube formation of endothelial cells. Anti-CD146 Antibody (AA98) enhances radiation-induced cancer cell apoptosis and survival inhibition, reduces tumor microvessel density, and suppresses tumor growth, invasion and vasculogenic mimicry. Anti-CD146 Antibody (AA98) can be used in research related to cervical cancer, liver cancer, malignant phyllodes tumor of the breast, uveal melanoma, leiomyosarcoma, pancreatic cancer, other tumors and angiogenesis.

HY-P991082

Anti-LAMP1/CD107a Antibody	Inhibitor
Anti-LAMP1/CD107a Antibody (SAR-428926 antibody) is an anti-LAMP1 humanized monoclonal antibody. Anti-LAMP1/CD107a Antibody can be used for the antibody part of SAR-428926. Antibody Anti-LAMP1/CD107a Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).

HY-P991912

PSB107	Inhibitor
PSB107 is a humanized anti-CD37 antibody. PSB107 can be used for the research of B-cell malignancies.

HY-P991840

Anti-CD68 Antibody (KP1)	Inhibitor
Anti-CD68 Antibody (KP1) is a anti-CD68 monoclonal antibody (mAb). CD68 is present in various cell types, including monocytes/macrophages and fibroblasts. Recommend Isotype Controls: Mouse IgG1 kappa, Isotype Control (HY-P99977).

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