2. Immunology/Inflammation GPCR/G Protein Stem Cell/Wnt MAPK/ERK Pathway Epigenetics
  3. Transmembrane Glycoprotein Arrestin ERK Epigenetic Reader Domain
  4. RWT9996

RWT9996 is a balanced GPR17 antagonist. RWT9996 has an inhibitory effect on G protein activation and β-arrestin-2 recruitment induced by MDL-29951. RWT9996 inhibits the phosphorylation of ERK/CREB and the accumulation of inositol phosphate (b IP1) induced by MDL-29951. RWT9996 can be used for the study of neurological diseases.

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RWT9996

RWT9996 Chemical Structure

CAS No. : 2877694-62-5

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RWT9996 Related Antibodies

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Description

RWT9996 is a balanced GPR17 antagonist. RWT9996 has an inhibitory effect on G protein activation and β-arrestin-2 recruitment induced by MDL-29951. RWT9996 inhibits the phosphorylation of ERK/CREB and the accumulation of inositol phosphate (b IP1) induced by MDL-29951. RWT9996 can be used for the study of neurological diseases[1].

Molecular Weight

341.36

Formula

C17H12FN3O2S
CAS No.
SMILES

FC1=C(NS(C2=CNC(C3=CC=CC=C3)=C2)(=O)=O)C=CC(C#N)=C1
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RWT9996 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RWT99962877694-62-5RWT 9996RWT-9996Transmembrane GlycoproteinArrestinERKEpigenetic Reader DomainExtracellular signal regulated kinasesmyelinationligand biasdrug discoveryG proteinβ-arrestinoligodendrocyteremyelinationbiased antagonismGPCR signalingInhibitorinhibitorinhibit

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