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Barbadin 

Cat. No.: HY-119706 Purity: >98.0%
Handling Instructions

Barbadin is a novel and selective β-arrestin/β2-adaptin interaction inhibitor, has IC50 values of 19.1 μM for β-arrestin1 and 15.6 μM for β-arrestin2. Barbadin blocks agonist-promoted endocytosis of the prototypical β2-adrenergic, V2-vasopressin and angiotensin-II type-1 receptors.

For research use only. We do not sell to patients.

Barbadin Chemical Structure

Barbadin Chemical Structure

CAS No. : 356568-70-2

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 174 In-stock
Estimated Time of Arrival: December 31
1 mg USD 55 In-stock
Estimated Time of Arrival: December 31
2 mg USD 95 In-stock
Estimated Time of Arrival: December 31
5 mg USD 160 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Barbadin is a novel and selective β-arrestin/β2-adaptin interaction inhibitor, has IC50 values of 19.1 μM for β-arrestin1 and 15.6 μM for β-arrestin2. Barbadin blocks agonist-promoted endocytosis of the prototypical β2-adrenergic, V2-vasopressin and angiotensin-II type-1 receptors[1].

IC50 & Target

IC50: 19.1 μM (β-arrestin1); 15.6 μM (β-arrestin2)[1]

Molecular Weight

333.41

Formula

C₁₉H₁₅N₃OS

CAS No.

356568-70-2

SMILES

O=C1C(C(C2=CC=C(CC3=CC=CC=C3)C=C2)=CS4)=C4N=CN1N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (149.97 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9993 mL 14.9966 mL 29.9931 mL
5 mM 0.5999 mL 2.9993 mL 5.9986 mL
10 mM 0.2999 mL 1.4997 mL 2.9993 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (7.50 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (7.50 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: >98.0%

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This equation is commonly abbreviated as: C1V1 = C2V2

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C1   V1   C2   V2

Keywords:

BarbadinOthersInhibitorinhibitorinhibit

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Product name:
Barbadin
Cat. No.:
HY-119706
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