2. Signaling Pathways
  3. Neuronal Signaling
  4. Transthyretin (TTR)
  5. Transthyretin (TTR) Inhibitor

Transthyretin (TTR) Inhibitor

Transthyretin (TTR) Inhibitors (7):

Cat. No. Product Name Effect Purity
  • HY-148089A
    Eplontersen sodium
    		Inhibitor
    Eplontersen sodium is a triantennary N-acetyl galactosamine (GalNAc3-7a)-conjugated antisense oligonucleotide targeting transthyretin (TTR) mRNA to inhibit production of both variant and wild-type TTR protein. Misfolded TTR induces amyloid fibrils formation in the heart and peripheral nerves, leads to amyloid TTR (ATTR) amyloidosis diseases.
  • HY-132590A
    Revusiran sodium
    		Inhibitor
    Revusiran sodium is a 1st-generation short interfering RNA, which directed against transthyretin (TTR) mRNA. Revusiran sodium can be used for transthyretin (TTR)-mediated amyloidosis research.
  • HY-155299
    PITB
    		Inhibitor
    PITB is a selective and orally active transthyretin (TTR) aggregation inhibitor. PITB can be used for transthyretin amyloidosis (ATTR) disease research.
  • HY-153609
    AS-Patisiran
    		Inhibitor
    Patisiran is a double-stranded small interfering RNA that targets a sequence within the transthyretin (TTR) messenger RNA. Patisiran specifically inhibits hepatic synthesis of mutant and wild-type TTR. Patisiran can be used for the research of hereditary TTR amyloidosis.
  • HY-153577
    WT-TTR inhibitor 1
    		Inhibitor 98.03%
    WT-TTR inhibitor 1 (Compound 21) is a wild-type Transthyretin (WT-TTR) inhibitor with 29.05% inhibition at 100 μM.
  • HY-148089
    Eplontersen
    		Inhibitor
    Eplontersen is a triantennary N-acetyl galactosamine (GalNAc3-7a)-conjugated antisense oligonucleotide targeting transthyretin (TTR) mRNA to inhibit production of both variant and wild-type TTR protein. Misfolded TTR induces amyloid fibrils formation in the heart and peripheral nerves, leads to amyloid TTR (ATTR) amyloidosis diseases.
  • HY-112974
    Inotersen
    		Inhibitor
    Inotersen is an antisense oligonucleotide that inhibits hepatic production of transthyretin (TTR).