Transthyretin-IN-3
Transthyretin-IN-3 (compound 6) is a designed benzofuran analogue. Transthyretin-IN-3 selectively binds to plasma transthyretin (TTR) to inhibit Amyloid aggregation (IC50=5.0±0.2 μM). Transthyretin-IN-3 can bind to TTR's thyroxine binding site specifically by carrying chlorine substituents at specific locations in its structure. This binding can prevent TTR tetramers from dissociating into unstable monomers.
For research use only. We do not sell to patients.
- CAS No.: 3008535-20-1
- Formula: C17H11ClI2O3
- Molecular Weight:552.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
Pharmacokinetic Analysis in SD rats[1]
| Route | Dose (mg/kg) | C0/max (ng/mL) | CLtot (mL/h/kg) | Vdss (mL/kg) | AUC0_8 (ng•h/mL) | BA (%) |
| i.v. | 0.1 | 1718 | 20.6 | 112 | 3726 | / |
| p.o. | 0.1 | 395 | / | / | 2524 | 67.7 |