3008535-20-1
Chemical Structure
Transthyretin-IN-3
- CAS. Nr.: 3008535-20-1
- Formula:C17H11ClI2O3
- Molecular Weight:552.53
InChIKey: ILLKLBYQVUHQGS-UHFFFAOYSA-N
SMILES: O=C(C1=C(CC)OC2=CC=CC(Cl)=C12)C3=CC(I)=C(O)C(I)=C3
Biological Activity: Transthyretin-IN-3 (compound 6) is a designed benzofuran analogue. Transthyretin-IN-3 selectively binds to plasma transthyretin (TTR) to inhibit Amyloid aggregation (IC50=5.0±0.2 μM). Transthyretin-IN-3 can bind to TTR's thyroxine binding site specifically by carrying chlorine substituents at specific locations in its structure. This binding can prevent TTR tetramers from dissociating into unstable monomers[1].
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Transthyretin-IN-3 | Transthyretin-IN-3 (compound 6) is a designed benzofuran analogue. Transthyretin-IN-3 selectively binds to plasma transthyretin (TTR) to inhibit Amyloid aggregation (IC50=5.0±0.2 μM). Transthyretin-IN-3 can bind to TTR's thyroxine binding site specifically by carrying chlorine substituents at specific locations in its structure. This binding can prevent TTR tetramers from dissociating into unstable monomers. | |||||||||||||||||||||
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Keywords
