1. GPCR/G Protein
  2. Adrenergic Receptor
  3. Vatinoxan hydrochloride

Vatinoxan hydrochloride (Synonyms: MK-467 hydrochloride; L-659066 hydrochloride)

Cat. No.: HY-19057A Purity: 99.25% ee.: 99.05%
Handling Instructions

Vatinoxan hydrochloride (MK-467 hydrochloride;L-659066 hydrochloride) is a peripheral α2 adrenergic receptor antagonist.

For research use only. We do not sell to patients.

Vatinoxan hydrochloride Chemical Structure

Vatinoxan hydrochloride Chemical Structure

CAS No. : 130466-38-5

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10 mM * 1 mL USD 1045 In-stock
Estimated Time of Arrival: December 31
5 mg USD 950 In-stock
Estimated Time of Arrival: December 31
10 mg USD 1700 In-stock
Estimated Time of Arrival: December 31
25 mg USD 3600 In-stock
Estimated Time of Arrival: December 31
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Description

Vatinoxan hydrochloride (MK-467 hydrochloride;L-659066 hydrochloride) is a peripheral α2 adrenergic receptor antagonist.

IC50 & Target

α2 adrenergic receptor[1]

In Vivo

Vatinoxan alone increases cardiac index and tissue oxygen delivery and has no deleterious adverse effects. Vatinoxan attenuates or prevents dexmedetomidine’s systemic hemodynamic effects in a dose-dependent manner when given simultaneously i.v. but has no effect on the pulmonary outcome in conscious dogs. A 50:1 dose ratio (Vatinoxan:dexmedetomidine) induces the least alterations in cardiovascular function[1]. Vatinoxan dose-dependently attenuates the bradycardia associated with dexmedetomidine, and shortens the sedative effect without altering its quality. Vatinoxan may be useful in attenuating reductions in heart rate in conscious catsadministered dexmedetomidine[2].

Molecular Weight

454.97

Formula

C₂₀H₂₇ClN₄O₄S

CAS No.

130466-38-5

SMILES

[H]Cl.CS(=O)(NCCN([[email protected]]1(CN2)CCN3CCC4=C(OC5=CC=CC=C54)[[email protected]]3([H])C1)C2=O)=O

Shipping

Room temperature in continental US; may vary elsewhere

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : ≥ 133 mg/mL (292.33 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1979 mL 10.9897 mL 21.9795 mL
5 mM 0.4396 mL 2.1979 mL 4.3959 mL
10 mM 0.2198 mL 1.0990 mL 2.1979 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Animal Administration
[1][2]

Dogs[1]

Eight dogs receive either dexmedetomidine (10 μg/kg), Vatinoxan (250 μg/kg or dexmedetomidine (10 μg/kg) with increasing doses of Vatinoxan (250 μg/kg, 500 μg/kg and 750 μg/kg). Treatments are given intravenously (i.v.) in a randomized, crossover design with a 14-day ishout period. Systemic hemodynamics and arterial blood gas analyses are recorded at baseline and at intervals up to 90 min after drugs administration[1].

Cats[2]

Cats are administered seven IV treatments are administered at least 2 weeks apart, consisting of dexmedetomidine 12.5 μg/kg (D12.5) and 25 μg/kg (D25), Vatinoxan 300 μg/kg (M300), and D25 combined with 75, 150, 300 and 600 μg/kg of Vatinoxan (D25M 75, D25M150, D25M300 and D25M600, respectively). Heart rates (HR) are recorded via telemetry and sedation assessed with a simple descriptive score and a visual analogue scale prior to treatments and at intervals until 8 hours thereafter[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Vatinoxan hydrochloride
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HY-19057A
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