AAK1-IN-3 TFA 

AAK1-IN-3 TFA, a quinoline analogue, is a brain-penetrant adaptor protein 2-associated kinase 1 (AAK1) inhibitor with an IC₅₀ of 11 nM. AAK1-IN-3 has the potential for neuropathic pain research^[1].

AAK1-IN-3 (compound (R)-31) TFA is brain-penetrant kinase inhibitors with a B/P ratio of 1.3^[1].
AAK1-IN-3 TFA inhibits AAK1 in HEK293 cells (IC50=108 nM)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AAK1-IN-3 (compound (R)-31; 30 mg/kg; sc; signle dose) TFA causes a 46% reduction of μ2 phosphorylation in C57BL6 mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

544.45

C₂₄H₂₂F₆N₄O₄

2761587-27-1

N#CC1=CC([C@H](N)CC(C)C)=NC2=CC=C(C3=CC=NC=C3)C=C12.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Richard A Hartz, et al. Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors. J Med Chem. 2022 Mar 10;65(5):4121-4155.  [Content Brief]