Acetyl-CoA Carboxylase-IN-1

Name: Acetyl-CoA Carboxylase-IN-1
Brand: MedChemExpress
SKU: HY-152117
Rating: 4.5 (1 reviews)

製品番号: HY-152117 純度: 99.16%: FAQs
Data Sheet SDS COA 取扱説明書

Molarity Calculator

Acetyl-CoA Carboxylase-IN-1 is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC₅₀ value of ＜5 nM. Acetyl-CoA Carboxylase-IN-1 has antibacterial activity.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Acetyl-CoA Carboxylase-IN-1 構造式

CAS 番号 : 179343-23-8

容量	価格（税別）	在庫状況	数量
無料サンプル (0.1 - 0.5 mg)		今すぐ申し込む
5 mg	USD 70	在庫あり	Estimated Time of Arrival: December 31
10 mg	USD 120	在庫あり	Estimated Time of Arrival: December 31
25 mg	USD 250	在庫あり	Estimated Time of Arrival: December 31
50 mg	USD 450	在庫あり	Estimated Time of Arrival: December 31
100 mg	USD 750	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 1 publication(s) in Google Scholar

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•関連タンパク質:

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

Acetyl-CoA Carboxylase-IN-1 is a potent acetyl-CoA carboxylase (ACC) inhibitor with an IC₅₀ value of ＜5 nM. Acetyl-CoA Carboxylase-IN-1 has antibacterial activity^[1].

体外実験

Acetyl-CoA Carboxylase-IN-1 (compound 1; 0.012-25 μM; E. coli) has antibacterial activity with MIC values of >25, 3.13, 25, 0.39, 1.56, 0.1 μM for WT, WT+ PMBN, ΔacrAB, ΔacrAB+PMBN, ΔtolC, and ΔtolC+ PMBN, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

395.05

分子式

C₁₃H₉Br₂N₅

CAS 番号

179343-23-8

Unlabeled CAS

Appearance

Solid

Color

Off-white to light yellow

SMILES

BrC1=C(C2=CC3=CN=C(N=C3N=C2N)N)C(Br)=CC=C1

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 33.33 mg/mL (84.37 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.5313 mL	12.6566 mL	25.3133 mL
5 mM	0.5063 mL	2.5313 mL	5.0627 mL
10 mM	0.2531 mL	1.2657 mL	2.5313 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 99.16%

Select Batch:

データシート (272 KB) SDS (393 KB)

COA (249 KB) HNMR (131 KB) RP-HPLC (169 KB) LCMS (383 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Cifone MT, et, al. Heterobivalent Inhibitors of Acetyl-CoA Carboxylase: Drug Target Residence Time and Time-Dependent Antibacterial Activity. J Med Chem. 2022 Dec 22;65(24):16510-16525. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.5313 mL	12.6566 mL	25.3133 mL	63.2831 mL
	5 mM	0.5063 mL	2.5313 mL	5.0627 mL	12.6566 mL
	10 mM	0.2531 mL	1.2657 mL	2.5313 mL	6.3283 mL
	15 mM	0.1688 mL	0.8438 mL	1.6876 mL	4.2189 mL
	20 mM	0.1266 mL	0.6328 mL	1.2657 mL	3.1642 mL
	25 mM	0.1013 mL	0.5063 mL	1.0125 mL	2.5313 mL
	30 mM	0.0844 mL	0.4219 mL	0.8438 mL	2.1094 mL
	40 mM	0.0633 mL	0.3164 mL	0.6328 mL	1.5821 mL
	50 mM	0.0506 mL	0.2531 mL	0.5063 mL	1.2657 mL
	60 mM	0.0422 mL	0.2109 mL	0.4219 mL	1.0547 mL
	80 mM	0.0316 mL	0.1582 mL	0.3164 mL	0.7910 mL