ALDH2 activator 1

Art. -Nr.: HY-176716 Reinheit: 98.88%: Data Sheet
COA

SDS
Handling Instructions
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ALDH2 activator 1 (Compound Z17) is an allosteric aldehyde dehydrogenase 2 (ALDH2) agonist. ALDH2 activator 1 enhances cardiac function and reduces myocardial necrosis in a mouse model of myocardial ischemia-reperfusion. ALDH2 activator 1 is promising for research of cardiovascular diseases such as myocardial infarction (MI).

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ALDH2 activator 1 Chemische Struktur

CAS. Nr. : 2988020-77-3

Größe	Verfügbarkeit	Menge
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	Auf Lager	Estimated Time of Arrival: December 31
Solid
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
25 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Auf Lager	Estimated Time of Arrival: December 31
100 mg	Auf Lager	Estimated Time of Arrival: December 31
200 mg	Angebot einholen
500 mg	Angebot einholen

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This product is a controlled substance and not for sale in your territory.

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Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Alle Aldehyde Dehydrogenase (ALDH) Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

ALDH1 ALDH2 ALDH3

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

IC₅₀ & Target

ALDH2

Molekulargewicht

430.86

Formel

C₂₁H₂₀ClFN₄O₃

CAS. Nr.

2988020-77-3

Appearance

Solid

Color

White to off-white

SMILES

O=C(NCC1=CC=C(OC)C(F)=C1)C2=C(OCC3CC3)C=CC(N4C=NN=C4)=C2Cl

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (232.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3209 mL	11.6047 mL	23.2094 mL
5 mM	0.4642 mL	2.3209 mL	4.6419 mL
10 mM	0.2321 mL	1.1605 mL	2.3209 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 98.88%

Select Batch:

Data Sheet (274 KB) SDS (251 KB)

COA (254 KB) HNMR (280 KB) LCMS (95 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Zhao F, et al. Design, Synthesis, and Protective Effect Evaluation on Myocardial Ischemia of New Triazole Aldehyde Dehydrogenase 2 Activators[J]. ACS Medicinal Chemistry Letters, 2025.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3209 mL	11.6047 mL	23.2094 mL	58.0235 mL
	5 mM	0.4642 mL	2.3209 mL	4.6419 mL	11.6047 mL
	10 mM	0.2321 mL	1.1605 mL	2.3209 mL	5.8023 mL
	15 mM	0.1547 mL	0.7736 mL	1.5473 mL	3.8682 mL
	20 mM	0.1160 mL	0.5802 mL	1.1605 mL	2.9012 mL
	25 mM	0.0928 mL	0.4642 mL	0.9284 mL	2.3209 mL
	30 mM	0.0774 mL	0.3868 mL	0.7736 mL	1.9341 mL
	40 mM	0.0580 mL	0.2901 mL	0.5802 mL	1.4506 mL
	50 mM	0.0464 mL	0.2321 mL	0.4642 mL	1.1605 mL
	60 mM	0.0387 mL	0.1934 mL	0.3868 mL	0.9671 mL
	80 mM	0.0290 mL	0.1451 mL	0.2901 mL	0.7253 mL
	100 mM	0.0232 mL	0.1160 mL	0.2321 mL	0.5802 mL