APC 366 TFA

Cat. No.: HY-105999B: Data Sheet
COA

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Handling Instructions
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APC 366 (TFA) is an irreversible mast cell tryptase inhibitor. APC 366 (TFA) can be used for the research of allergic diseases.

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APC 366 TFA 화학구조

CAS No. : 2421110-28-1

사이즈	가격	재고
1 mg		Ask For Quote & Lead Time

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of APC 366 TFA:

APC 366

Other Forms of APC 366 TFA:

APC 366 In-stock
APC 366 hydrochloride 견적 받기

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

APC 366 (TFA) is an irreversible mast cell tryptase inhibitor. APC 366 (TFA) can be used for the research of allergic diseases^[1].

IC₅₀ & Target

mast cell tryptase^[1]

In Vivo

APC 366 (TFA) (5 mg/kg/0.1 ml; s.c.) reduces the eosinophil recruitment induced by PAR-2 activating peptide^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Male BALB/c mice (18–25 g)^[1]
Dosage:	5 mg/kg/0.1 ml
Administration:	S.c.
Result:	Reduced the eosinophil recruitment induced by PAR-2 activating peptide.

분자량

554.52

화학식

C₂₄H₂₉F₃N₆O₆

CAS No.

2421110-28-1

Appearance

Solid

Color

White to off-white

SMILES

OC(C(F)(F)F)=O.OC1=C(C(N[C@@H](CCCNC(N)=N)C(N2[C@@H](CCC2)C(N)=O)=O)=O)C=CC3=C1C=CC=C3

선적

Room temperature in continental US; may vary elsewhere.

보관

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

순도&문서

Purity: ≥99.0%

Select Batch:

Data Sheet (265 KB) SDS (251 KB)

COA (246 KB)

Handling Instructions (2659 KB)

References

[1]. Matos NA, et al. Mast cell tryptase induces eosinophil recruitment in the pleural cavity of mice via proteinase-activated receptor 2. Inflammation. 2013;36(6):1260-1267. [Content Brief]

APC 366 TFA Related Classifications

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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

APC 3662421110-28-1APC366APC-366Protease Activated Receptor (PAR)Thrombin receptorsirreversiblemasttryptaseallergiceosinophilrecruitmentPAR-2Inhibitorinhibitorinhibit

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