2. GPCR/G Protein
  3. Apelin Receptor (APJ)
  4. Apelin-13

Apelin-13 is an endogenous ligand for the G-protein coupled receptor angiotensin II protein J (APJ), activating this G protein-coupled receptor with an EC 50 value of 0.37 nM. Apelin-13 is widely distributed in the central and peripheral nervous systems. Apelin-13 has vasodilatory and antihypertensive effects. Apelin-13 also can be used for researching type 2 diabetes and metabolic syndrome.

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No. CAS : 217082-58-1

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Revisión del cliente

Based on 10 publication(s) in Google Scholar

Other Forms of Apelin-13:

Apelin-13 Related Antibodies

Top Publications Citing Use of Products

    Apelin-13 purchased from MedChemExpress. Usage Cited in: Ren Fail. 2025 Dec;47(1):2480243.  [Abstract]

    Apelin-13 (30 μg/kg) treatment improved renal function and reduced tubulointerstitial injury. PAS staining (×200) showed histological changes in the kidneys of each group.

    Apelin-13 purchased from MedChemExpress. Usage Cited in: Stem Cells Int. 2022 Mar 21;2022:3742678.  [Abstract]

    CCK-8 assay showed the cell viability of MSCs with or without Apelin-13 (0.01, 0.05, 0.1, 0.5, and 1 nM) pretreatment for 24 hours under normoxic or SD/H conditions.

    Apelin-13 purchased from MedChemExpress. Usage Cited in: Stem Cells Int. 2022 Mar 21;2022:3742678.  [Abstract]

    Representative images of MitoTracker staining and quantitative analysis of the mitochondrial number and mean mitochondrial area in MSCs and Apelin-13 (0.1 nM)-pretreated MSCs under normoxic or SD/H conditions.

    Apelin-13 purchased from MedChemExpress. Usage Cited in: Stem Cells Int. 2022 Mar 21;2022:3742678.  [Abstract]

    Western blotting and quantitative analysis of the protein level of Mfn1/2 and p-Drp1 ser616 in MSCs and Apelin-13-pretreated MSCs under normoxia or SD/H challenge.

    Apelin-13 purchased from MedChemExpress. Usage Cited in: Stem Cells Int. 2022 Mar 21;2022:3742678.  [Abstract]

    Representative images of Annexin V/PI staining and quantitative analysis of the apoptotic rate in MSCs and Apelin-13 (0.1 nM)-pretreated MSCs under normoxic or SD/H conditions.

    • Actividad biológica

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    Descripciòn

    Apelin-13 is an endogenous ligand for the G-protein coupled receptor angiotensin II protein J (APJ), activating this G protein-coupled receptor with an EC 50 value of 0.37 nM. Apelin-13 is widely distributed in the central and peripheral nervous systems. Apelin-13 has vasodilatory and antihypertensive effects. Apelin-13 also can be used for researching type 2 diabetes and metabolic syndrome[1][2][3].

    IC50 & Target

    IC50: 0.37 nM (APJ)[1]
    Cellular Effect
    Cell Line Type Value Description References
    CHO EC50
    0.87 1
    Compound: Apelin-13, QRPRLSHKGPMPF
    Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
    Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
    		[PMID: 24755525]
    CHO EC50
    0.87 1
    Compound: Apelin-13, QRPRLSHKGPMPF
    Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
    Agonist activity at APJ receptor (unknown origin) expressed in CHO cells co-expressing with Calphaq16 assessed as calcium mobilization
    		[PMID: 24755525]
    In Vivo

    Apelin-13 (200 µg/kg; IP, daily for 4 weeks) improves cardiac function, improves insulin resistance, improves lipid metabolism, significantly decreases TNF-α and leptin on serum, induces the expression of Apelin-12 in serum and markedly elevates GLUT4 and p-AMPKα2 levels[2].
    Apelin-13 (10 and 100 μM; ICV, single dosage) increases the spontaneous discharges in the majority of pallidal neurons[4].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Goto-Kakizaki (GK) rats (12 weeks old; 240-280 g; fed with a high-fat diet: 66.5% standard chow, 10% lard, 20% sucrose, 2.5% cholesterol and 1% pig bile salt)[2]
    Dosage: 200 µg/kg
    Administration: IP, daily for 4 weeks
    Result: Significantly decreased heart rate; lowered the levels of fasting plasma glucose (FPG), fasting insulin (FINS) and homeostasis model assessment for insulin resistancey (HOMA-IR); decreased serum levels of total cholesterol (TC), triglyceride (TG) and low density lipoprotein-cholesterol (LDL-C) and increased high density lipoprotein-cholesterol (HDL-C); decreased NO level, cNOS activity, TNF-α and leptin in serum; induced the expression of Apelin-12.
    Animal Model: Adult Wistar rats (SPF, 8-10 weeks, 240-280 g)[4]
    Dosage: 10 and100 μM
    Administration: ICV, single dosage
    Result: Increased the spontaneous discharges in the majority of pallidal neurons.
    Ensayo clínico
    Peso molecular

    1550.83

    Fòrmula

    C69H111N23O16S
    No. CAS
    Appearance

    Solid

    Color

    White to off-white

    Sequence

    Gln-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe
    Sequence Shortening

    QRPRLSHKGPMPF
    Envío

    Room temperature in continental US; may vary elsewhere.
    Almacenamiento

    Sealed storage, away from moisture

    Powder -80°C 2 years
    -20°C 1 year

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

    Solvente y solubilidad
    In Vitro: 

    DMSO : 100 mg/mL (64.48 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.6448 mL 3.2241 mL 6.4482 mL
    5 mM 0.1290 mL 0.6448 mL 1.2896 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Calculadora de molaridad

    • Calculadora de dilución

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass
    =
    Concentration
    ×
    Volume
    ×
    Molecular Weight *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

    C1

    ×
    Volume (start)

    V1

    =
    Concentration (final)

    C2

    ×
    Volume (final)

    V2

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

    Animal weight
    (per animal)

    g

    Dosing volume
    (per animal)

    μL

    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Pureza y Documentación
    Referencias

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 0.6448 mL 3.2241 mL 6.4482 mL 16.1204 mL
    5 mM 0.1290 mL 0.6448 mL 1.2896 mL 3.2241 mL
    10 mM 0.0645 mL 0.3224 mL 0.6448 mL 1.6120 mL
    15 mM 0.0430 mL 0.2149 mL 0.4299 mL 1.0747 mL
    20 mM 0.0322 mL 0.1612 mL 0.3224 mL 0.8060 mL
    25 mM 0.0258 mL 0.1290 mL 0.2579 mL 0.6448 mL
    30 mM 0.0215 mL 0.1075 mL 0.2149 mL 0.5373 mL
    40 mM 0.0161 mL 0.0806 mL 0.1612 mL 0.4030 mL
    50 mM 0.0129 mL 0.0645 mL 0.1290 mL 0.3224 mL
    60 mM 0.0107 mL 0.0537 mL 0.1075 mL 0.2687 mL
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    Apelin-13 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Apelin-13217082-58-1Apelin13Apelin 13Apelin Receptor (APJ)nervous systemsvasodilatoryantihypertensivediabetesmetabolic syndromeinsulin resistancelipidpallidal neuronsGoto-Kakizaki ratWistar ratInhibitorinhibitorinhibit

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    Nombre del producto:
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    Cat. No.:
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