2. Immunology/Inflammation
  3. FAP
  4. ARI-3144

ARI-3144 is an excellent and specific substrate for fibroblast activation protein (FAP). ARI-3144 is usually coupled with the fluorophore 7-Amino-4-methylcoumarin (HY-D0027) (AMC) for detection and quantification of FAP.

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ARI-3144

ARI-3144 Chemical Structure

CAS No. : 1426305-25-0

Size Prix Stock Quantité
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
Solid
5 mg En stock
10 mg En stock
25 mg En stock
50 mg En stock
100 mg En stock
200 mg   Obtenir un devis  
500 mg   Obtenir un devis  

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ARI-3144 Related Antibodies

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  • Activité biologique

  • Pureté et documentation

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Description

ARI-3144 is an excellent and specific substrate for fibroblast activation protein (FAP). ARI-3144 is usually coupled with the fluorophore 7-Amino-4-methylcoumarin (HY-D0027) (AMC) for detection and quantification of FAP[1].

Masse moléculaire

498.53

Formule

C28H26N4O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N1[C@@H](CCC1)C(NC2=CC=C(C(C)=CC(O3)=O)C3=C2)=O)[C@@H](C)NC(C4=CC=NC5=C4C=CC=C5)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvant et solubilité
In Vitro: 

DMSO : 100 mg/mL (200.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0059 mL 10.0295 mL 20.0590 mL
5 mM 0.4012 mL 2.0059 mL 4.0118 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculateur de molarité

  • Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureté et documentation
Références

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0059 mL 10.0295 mL 20.0590 mL 50.1474 mL
5 mM 0.4012 mL 2.0059 mL 4.0118 mL 10.0295 mL
10 mM 0.2006 mL 1.0029 mL 2.0059 mL 5.0147 mL
15 mM 0.1337 mL 0.6686 mL 1.3373 mL 3.3432 mL
20 mM 0.1003 mL 0.5015 mL 1.0029 mL 2.5074 mL
25 mM 0.0802 mL 0.4012 mL 0.8024 mL 2.0059 mL
30 mM 0.0669 mL 0.3343 mL 0.6686 mL 1.6716 mL
40 mM 0.0501 mL 0.2507 mL 0.5015 mL 1.2537 mL
50 mM 0.0401 mL 0.2006 mL 0.4012 mL 1.0029 mL
60 mM 0.0334 mL 0.1672 mL 0.3343 mL 0.8358 mL
80 mM 0.0251 mL 0.1254 mL 0.2507 mL 0.6268 mL
100 mM 0.0201 mL 0.1003 mL 0.2006 mL 0.5015 mL
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ARI-3144 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ARI-31441426305-25-0ARI3144ARI 3144FAPFibroblast activation proteinsolid tumorsproteasome inhibitorsubstrateInhibitorinhibitorinhibit

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Nom du produit:
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Cat. No.:
HY-160289
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