2. Metabolic Enzyme/Protease
  3. Factor Xa
  4. Asundexian

Asundexian  (Synonyms: BAY-2433334)

製品番号: HY-137431 純度: 99.80%
COA 取扱説明書 Technical Support

Asundexian (BAY 2433334) is an orally active coagulation factor Xia (FXIa) inhibitor. Asundexian binds directly, potently, and reversibly to the active site of FXIa and thereby inhibits its activity. Asundexian inhibits human FXIa in buffer with an IC50 of 1 nM.

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Asundexian

Asundexian 構造式

CAS 番号 : 2064121-65-7

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 757 在庫あり
Solution
10 mM * 1 mL in DMSO USD 757 在庫あり
Solid
1 mg $232 在庫あり
5 mg $580 在庫あり
10 mg $950 在庫あり
25 mg $1850 在庫あり
50 mg $2980 在庫あり
100 mg $4900 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Based on 5 publication(s) in Google Scholar

Other Forms of Asundexian:

Asundexian 関連抗体

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製品説明

Asundexian (BAY 2433334) is an orally active coagulation factor Xia (FXIa) inhibitor. Asundexian binds directly, potently, and reversibly to the active site of FXIa and thereby inhibits its activity. Asundexian inhibits human FXIa in buffer with an IC50 of 1 nM[1].

体内実験

Asundexian displays potent anticoagulant activity in vitro in human and rabbit plasma and antithrombotic efficacy in vivo in a rabbit arterial thrombosis model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
臨床実験
分子量

592.93

分子式

C26H21ClF4N6O4
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

COC(C(C1=C(N2C=C(N=N2)C(F)(F)F)C=CC(Cl)=C1)=C3)=CN([C@@H](CC)C(NC4=CC(F)=C(C=C4)C(N)=O)=O)C3=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : ≥ 250 mg/mL (421.63 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6865 mL 8.4327 mL 16.8654 mL
5 mM 0.3373 mL 1.6865 mL 3.3731 mL
10 mM 0.1687 mL 0.8433 mL 1.6865 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6865 mL 8.4327 mL 16.8654 mL 42.1635 mL
5 mM 0.3373 mL 1.6865 mL 3.3731 mL 8.4327 mL
10 mM 0.1687 mL 0.8433 mL 1.6865 mL 4.2163 mL
15 mM 0.1124 mL 0.5622 mL 1.1244 mL 2.8109 mL
20 mM 0.0843 mL 0.4216 mL 0.8433 mL 2.1082 mL
25 mM 0.0675 mL 0.3373 mL 0.6746 mL 1.6865 mL
30 mM 0.0562 mL 0.2811 mL 0.5622 mL 1.4054 mL
40 mM 0.0422 mL 0.2108 mL 0.4216 mL 1.0541 mL
50 mM 0.0337 mL 0.1687 mL 0.3373 mL 0.8433 mL
60 mM 0.0281 mL 0.1405 mL 0.2811 mL 0.7027 mL
80 mM 0.0211 mL 0.1054 mL 0.2108 mL 0.5270 mL
100 mM 0.0169 mL 0.0843 mL 0.1687 mL 0.4216 mL
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Asundexian Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Asundexian2064121-65-7BAY-2433334BAY2433334BAY 2433334Factor XaFxaanticoagulantfactorXIhemostasisthrombosisInhibitorinhibitorinhibit

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