Azide-PEG4-VC-PAB-Doxorubicin

Name: Azide-PEG4-VC-PAB-Doxorubicin
Brand: MedChemExpress
SKU: HY-136288
Rating: 4.5 (0 reviews)

Cat. No.: HY-136288 Pureté: 99.62%: Fiche technique
COA

SDS
Instruction de manipulation
FAQs
Technical Support

Azide-PEG4-VC-PAB-Doxorubicin is a agent-linker conjugate composed of a cytotoxic anthracycline antibiotic Doxorubicin and a linker Azide-PEG4-VC-PAB to make antibody agent conjugate (ADC). Azide-PEG4-VC-PAB-Doxorubicin is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Azide-PEG4-VC-PAB-Doxorubicin Chemical Structure

Size	Stock	Quantité
1 mg	En stock	Estimated Time of Arrival: December 31
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtenir un devis
500 mg	Obtenir un devis

or Bulk Inquiry

* Veuillez sélectionner la quantité avant d'ajouter des articles.

This product is a controlled substance and not for sale in your territory.

Avis client

Based on 1 Customer Validation

Recommandations en vedette

•Related Small Molecules:

•Related Proteins:

Voir tous les produits spécifiques à Isoform Drug-Linker Conjugates for ADC:

Voir toutes les isoformes

Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

Activité biologique
Pureté et documentation
Références
Avis client

Description

Azide-PEG4-VC-PAB-Doxorubicin is a agent-linker conjugate composed of a cytotoxic anthracycline antibiotic Doxorubicin and a linker Azide-PEG4-VC-PAB to make antibody agent conjugate (ADC)^[1]. Azide-PEG4-VC-PAB-Doxorubicin is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC₅₀ & Target^[1]

Daunorubicins/Doxorubicins

In Vitro

Antibody-drug conjugates (ADCs) carry a highly potent small-molecule toxin covalently connected on the antibody via a proper linker. For therapeutic ADCs in cancer treatment, the antibody targets specific antigen of tumor cell surface with high binding affinity, thereafter the intact ADC was internalized into the tumor cells with the antigen and digested in the lysosome to release the antitumor toxin^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Masse moléculaire

1222.25

Formule

C₅₇H₇₅N₉O₂₁

Appearance

Solid

Color

Orange to red

SMILES

O[C@@](CC1=C2O)(C[C@@H](C1=C(C(C(C3=C4C=CC=C3OC)=O)=C2C4=O)O)O[C@H]5C[C@@H]([C@@H]([C@@H](O5)C)O)NC(OCC6=CC=C(NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCOCCOCCN=[N+]=[N-])=O)=O)=O)C=C6)=O)C(CO)=O

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (81.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.8182 mL	4.0908 mL	8.1816 mL
5 mM	0.1636 mL	0.8182 mL	1.6363 mL
10 mM	0.0818 mL	0.4091 mL	0.8182 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculateur de molarité
Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureté et documentation

Purity: 99.62%

Select Batch:

Fiche technique (268 KB) SDS (252 KB)

COA (246 KB) HNMR (486 KB) RP-HPLC (248 KB) MS (72 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Hayward R, et al. Doxorubicin cardiotoxicity in the rat: an in vivo characterization. J Am Assoc Lab Anim Sci. 2007 Jul;46(4):20-32. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.8182 mL	4.0908 mL	8.1816 mL	20.4541 mL
	5 mM	0.1636 mL	0.8182 mL	1.6363 mL	4.0908 mL
	10 mM	0.0818 mL	0.4091 mL	0.8182 mL	2.0454 mL
	15 mM	0.0545 mL	0.2727 mL	0.5454 mL	1.3636 mL
	20 mM	0.0409 mL	0.2045 mL	0.4091 mL	1.0227 mL
	25 mM	0.0327 mL	0.1636 mL	0.3273 mL	0.8182 mL
	30 mM	0.0273 mL	0.1364 mL	0.2727 mL	0.6818 mL
	40 mM	0.0205 mL	0.1023 mL	0.2045 mL	0.5114 mL
	50 mM	0.0164 mL	0.0818 mL	0.1636 mL	0.4091 mL
	60 mM	0.0136 mL	0.0682 mL	0.1364 mL	0.3409 mL
	80 mM	0.0102 mL	0.0511 mL	0.1023 mL	0.2557 mL