Barusiban  (Synonyms: FE-200440)

Barusiban (FE-200440) is an oxytocin receptor (OT-R) antagonist (K_i=0.8 nM), inhibits OT-induced contraction. Barusiban can be used in preterm labor (PTL), in vitro fertilisation (IVF) and infertility research^[1][2][3].

Barusiban shows affinity for oxytocin receptor (K_i=0.8 nM) in COS cells expressed with oxytocin receptor^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Barusiban (intravenous injection; 50 or 150 μg/kg; once) treatment shows inhibition on OT-induced contractions^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

830.05

C₄₀H₆₃N₉O₈S

285571-64-4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Helmer H, et al. Barusiban, a selective oxytocin receptor antagonist: placental transfer in rabbit, monkey, and human†. Biol Reprod. 2020 Jun 23;103(1):135-143.  [Content Brief]

  [2]. Reinheimer TM, et al. Barusiban, a new highly potent and long-acting oxytocin antagonist: pharmacokinetic and pharmacodynamic comparison with atosiban in a cynomolgus monkey model of preterm labor. J Clin Endocrinol Metab. 2005 Apr;90(4):2275-81.  [Content Brief]

  [3]. Gimpl G, et al. Binding domains of the oxytocin receptor for the selective oxytocin receptor antagonist barusiban in comparison to the agonists oxytocin and carbetocin. Eur J Pharmacol. 2005 Mar 7;510(1-2):9-16.  [Content Brief]