285571-64-4
285571-64-4
Chemical Structure
Barusiban
Synonym(s): FE-200440
- CAS No.: 285571-64-4
- Formula:C40H63N9O8S
- Molecular Weight:830.05
InChIKey: UGNGRKKDUVKQDF-IHOMMZCZSA-N
SMILES: O=C(N[C@@](C(N[C@@](C(N[C@H](C(N[C@@H](CCSCCC(N1)=O)C(N(C)[C@H](CO)CCCN)=O)=O)CC(N)=O)=O)([H])[C@H](C)CC)=O)([H])[C@@H](C)CC)[C@H]1CC2=CNC3=CC=CC=C23
Biological Activity: Barusiban (FE-200440) is an oxytocin receptor (OT-R) antagonist (Ki=0.8 nM), inhibits OT-induced contraction. Barusiban can be used in preterm labor (PTL), in vitro fertilisation (IVF) and infertility research[1][2][3].
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Barusiban | Barusiban (FE-200440) is an oxytocin receptor (OT-R) antagonist (Ki=0.8 nM), inhibits OT-induced contraction. Barusiban can be used in preterm labor (PTL), in vitro fertilisation (IVF) and infertility research. | |||||||||||||||||||||
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References
- [1]. Helmer H, et al. Barusiban, a selective oxytocin receptor antagonist: placental transfer in rabbit, monkey, and human†. Biol Reprod. 2020 Jun 23;103(1):135-143. [Content Brief]
- [2]. Reinheimer TM, et al. Barusiban, a new highly potent and long-acting oxytocin antagonist: pharmacokinetic and pharmacodynamic comparison with atosiban in a cynomolgus monkey model of preterm labor. J Clin Endocrinol Metab. 2005 Apr;90(4):2275-81. [Content Brief]
- [3]. Gimpl G, et al. Binding domains of the oxytocin receptor for the selective oxytocin receptor antagonist barusiban in comparison to the agonists oxytocin and carbetocin. Eur J Pharmacol. 2005 Mar 7;510(1-2):9-16. [Content Brief]
