2. GPCR/G Protein
  3. Oxytocin Receptor
  4. Barusiban

Barusiban (FE-200440) is an oxytocin receptor (OT-R) antagonist (Ki=0.8 nM), inhibits OT-induced contraction. Barusiban can be used in preterm labor (PTL), in vitro fertilisation (IVF) and infertility research.

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Barusiban

Barusiban 화학구조

CAS No. : 285571-64-4

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Barusiban Related Antibodies

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제품 설명

Barusiban (FE-200440) is an oxytocin receptor (OT-R) antagonist (Ki=0.8 nM), inhibits OT-induced contraction. Barusiban can be used in preterm labor (PTL), in vitro fertilisation (IVF) and infertility research[1][2][3].

In Vitro

Barusiban shows affinity for oxytocin receptor (Ki=0.8 nM) in COS cells expressed with oxytocin receptor[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Barusiban Related Antibodies
In Vivo

Barusiban (intravenous injection; 50 or 150 μg/kg; once) treatment shows inhibition on OT-induced contractions[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pregnant cynomolgus monkeys injected with oxytocin (OT)[2]
Dosage: 50 or 150 μg/kg
Administration: Intravenous injection; 50 or 150 μg/kg; once
Result: Reduced uterine contractions to baseline levels effectively.
Reduced intrauterine pressure (IUP) from 6-7.5 kmm Hg•h to approximately 1 kmm Hg•h.
Clinical Trial
분자량

830.05

화학식

C40H63N9O8S
CAS No.
선적

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Keywords:

Barusiban285571-64-4FE-200440FE200440FE 200440Oxytocin ReceptorOXTROT-induced contractionpreterm laborPTLin vitro fertilisationIVFinfertilityInhibitorinhibitorinhibit

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Barusiban
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HY-P3516
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