2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. BMS-986497

BMS-986497 (ORM-6151) is a CD33-targeting antibody-conjugated GSPT1 degrader. BMS-986497 delivers the GSPT1 degrader SMol006 to CD33-expressing cells and induces GSPT1 protein degradation. BMS-986497 shows potential for research on acute myeloid leukemia (AML).

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BMS-986497

BMS-986497 화학구조

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BMS-986497 Related Antibodies

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제품 설명

BMS-986497 (ORM-6151) is a CD33-targeting antibody-conjugated GSPT1 degrader. BMS-986497 delivers the GSPT1 degrader SMol006 to CD33-expressing cells and induces GSPT1 protein degradation. BMS-986497 shows potential for research on acute myeloid leukemia (AML)[1][2].

In Vitro

ORM-6151 (BMS-986497) (picomolar concentrations) shows picomolar cytotoxic activity in CD33-expressing AML cell lines, including Mylotarg-resistant AML193 and Kasumi6 cell lines, with 10-1000-fold greater potency than reference GSPT1 degrader molecules[1].
ORM-6151 (BMS-986497) (picomolar concentrations) shows picomolar cytotoxic potency in primary relapsed/refractory AML patient blasts, with better potency than CC-90009 and Mylotarg[1].
ORM-6151 (BMS-986497) exhibits minimal cytotoxic activity in healthy hematopoietic progenitor cells, with 10-10,000-fold less toxicity than CC-90009 or Mylotarg[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BMS-986497 Related Antibodies
In Vivo

ORM-6151 (BMS-986497) (1 mg/kg; single treatment) delivers robust, superior anti-tumor activity relative to CC-90009 in the MV4-11 AML xenograft model, with efficacy correlating to GSPT1 depletion and integrated stress response biomarker expression changes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: xenograft model[1]
Dosage: 1 mg/kg
Administration: single treatment
Result: Demonstrated robust anti-tumor efficacy, with superior activity compared to CC-90009.
Showed tumor growth inhibition correlated with the degree and duration of GSPT1 depletion and changes in expression of integrated stress response biomarker genes.
Clinical Trial
SMILES

[BMS-986497]
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순도&문서
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BMS-986497 Related Classifications

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Keywords:

BMS-986497ORM-6151BMS986497BMS 986497ORM6151ORM 6151Transmembrane GlycoproteinCD33acute myeloid leukemia xenograft modelsmyelodysplastic neoplasmsAML193Kasumi6acute myeloid leukemia cellshealthy hematopoietic progenitor cellsMV4-11GSPT1primary relapsed/refractory acute myeloid leukemia blastsInhibitorinhibitorinhibit

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상품명:
BMS-986497
Cat. No.:
HY-171792
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