Breast cancer targeting peptide 18–4

Cat. No.: HY-P10790: Ficha de datos Instrucciones de manejo
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Breast cancer targeting peptide 18–4 is a KRT1 receptor-targeting peptide, with a K_d of 0.98 μM. The amino acid sequence of Breast cancer targeting peptide 18–4 is WxEAAYQrFL, and it is an analogue of P160 peptide (HY-P10789). When covalently conjugated with the anticancer peptide MccJ25, Breast cancer targeting peptide 18–4 significantly increases the cellular uptake of MccJ25 in breast cancer cells and enhances its anticancer activity. The covalent conjugate exhibits IC₅₀ values of 14.2, 20, and 25 μM against MCF-7, MDA-MB-435, and MDA-MB-435-MDR cells, respectively.

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Breast cancer targeting peptide 18–4 Estructura química

No. CAS : 1332850-08-4

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Descripciòn	Breast cancer targeting peptide 18–4 is a KRT1 receptor-targeting peptide, with a K_d of 0.98 μM. The amino acid sequence of Breast cancer targeting peptide 18–4 is WxEAAYQrFL, and it is an analogue of P160 peptide (HY-P10789). When covalently conjugated with the anticancer peptide MccJ25, Breast cancer targeting peptide 18–4 significantly increases the cellular uptake of MccJ25 in breast cancer cells and enhances its anticancer activity. The covalent conjugate exhibits IC₅₀ values of 14.2, 20, and 25 μM against MCF-7, MDA-MB-435, and MDA-MB-435-MDR cells, respectively^[1].
Peso molecular	1296.47
Fòrmula	C₆₃H₈₉N₁₅O₁₅
No. CAS	1332850-08-4
Sequence	Trp-{d-Nle}-Glu-Ala-Ala-Tyr-Gln-{d-Arg}-Phe-Leu
Sequence Shortening	W-{d-Nle}-EAAYQ-{d-Arg}-FL
Envío	Room temperature in continental US; may vary elsewhere.
Almacenamiento	Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación	Ficha de datos (259 KB) Instrucciones de manejo (2659 KB)
Referencias	[1]. Soudy R, et al. Breast Cancer Targeting Peptide Binds Keratin 1: A New Molecular Marker for Targeted Drug Delivery to Breast Cancer. Mol Pharm. 2017 Mar 6;14(3):593-604. [Content Brief]