2. Antibody-drug Conjugate/ADC Related Cell Cycle/DNA Damage Cytoskeleton
  3. Antibody-Drug Conjugates (ADCs) Microtubule/Tubulin
  4. Cantuzumab mertansine

Cantuzumab mertansine  (Synonyms: SB-408075; huC242-DM1)

製品番号: HY-P99492 純度: 96.02%
COA 取扱説明書 Technical Support

Cantuzumab mertansine (SB-408075; huC242-DM1), an ADC, is an immunoconjugate of the potent maytansine derivative (DM1 (HY-19792)) and the humanized monoclonal antibody (huC242) directed to CanAg. Cantuzumab mertansine has cytotoxic toward colon cancer cells and has broad antitumor efficacy against a range of CanAg-positive human tumor xenografts.

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Cantuzumab mertansine

Cantuzumab mertansine 構造式

CAS 番号 : 400010-39-1

容量 価格（税別） 在庫状況 数量
1 mg $485 在庫あり
5 mg $1500 在庫あり
10 mg $2400 在庫あり
25 mg $4800 在庫あり
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Cantuzumab mertansine 関連抗体

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製品説明

Cantuzumab mertansine (SB-408075; huC242-DM1), an ADC, is an immunoconjugate of the potent maytansine derivative (DM1 (HY-19792)) and the humanized monoclonal antibody (huC242) directed to CanAg. Cantuzumab mertansine has cytotoxic toward colon cancer cells and has broad antitumor efficacy against a range of CanAg-positive human tumor xenografts[1][2].

体外実験

Cantuzumab mertansine (SB-408075; huC242-DM1; 0-100 μM; 24 h) has selective cytotoxic activity on antigen-positive COLO 205 cell line[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cantuzumab mertansine 関連抗体

Cell Cytotoxicity Assay[1]

Cell Line: Antigen-positive COLO 205 cell line and the antigen-negative A-375 melanoma cell line
Concentration: 0-100 μM
Incubation Time: 24 h
Result: Had cytotoxic activity on COLO 205 cells with an IC50 value of 0.032 nM (23.5 pg/ml).
Had 1100-fold less cytotoxic activity for the antigen-negative A-375 cells (IC50=36 nM; 26.5 ng/ml).
体内実験

Cantuzumab mertansine (SB-408075; huC242-DM1; 300 μg/kg/day for 5 days) resultes in complete regressions and cures of mice bearing human xenografts of COLO 205 colon cancer[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female CB-17 SCID mice, 6-7 weeks of age bearing COLO 205 human colon tumor xenografts[1]
Dosage: 300 μg/kg
Administration: Daily for 5 days
Result: Completely eliminated any measurable tumors within 2 weeks of the initiation of therapy, and all eight animals were tumor-free for 200 days (duration of the experiment).
分子量

150000 (average)

CAS 番号
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Cantuzumab mertansine]
輸送条件

Shipping with dry ice.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
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Cantuzumab mertansine Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cantuzumab mertansine400010-39-1SB-408075 huC242-DM1SB408075SB 408075Antibody-Drug Conjugates (ADCs)Microtubule/TubulinAntibody-Drug ConjugatesADCimmunoconjugatemaytansinehuC242CanAgcolon cancerColo 205HT-29LoVoInhibitorinhibitorinhibit

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Cantuzumab mertansine
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