Captopril hydrochloride (Synonyms: SQ 14225 hydrochloride)

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Captopril (SQ 14225) hydrochloride, antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril hydrochloride is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC₅₀ of 7.9 μM.

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CAS. Nr. : 198342-23-3

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Other In-stock Forms of Captopril hydrochloride:

Captopril

Other Forms of Captopril hydrochloride:

Epicaptopril In-stock
Captopril In-stock
epi-D-Captopril Angebot einholen

22 Publications Citing Use of MCE Captopril hydrochloride

In Vivo Efficacy Study

Histological Imaging/Staining

: Captopril hydrochloride purchased from MedChemExpress. Usage Cited in: Allergy. 2025 Nov 14. [Abstract]; Representative images of feet collected 30 min post-Evans Blue (EB) injection. Mice were assigned to five groups: WT control, Serping1^+/− control, WT + Captopril (2.5 mg/kg; i.v.), Serping1^+/− + Captopril + PBS, and Serping1^+/− + Captopril + AAV-NG-ABE8e. Captopril elicited significant Evans blue leakage.

: Captopril hydrochloride purchased from MedChemExpress. Usage Cited in: Allergy. 2025 Nov 14. [Abstract]; Representative intravital confocal images showing real-time FITC-dextran extravasation from intestinal microvasculature. Mice were assigned to: WT control, Serping1^+/− control, WT + Captopril (2.5 mg/kg; i.v.), Serping1^+/− + Captopril + PBS, and Serping1^+/− + Captopril + AAV-NG-ABE8e. By 30 min, Captopril-treated mice demonstrated pronounced FITC-dextran extravasation—both in area and fluorescence intensity—relative to WT and Serping1^+/− controls.

: Captopril hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 May 2;14(1):2523. [Abstract]; Serum BK levels from sWAT from WT male mice treated with 40 mg/kg/day Captopril or 70 mg/kg/day Enalapril by gavage once a day for 21 days. The results showed that Captopril significantly increased serum BK levels.

: Captopril hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 May 2;14(1):2523. [Abstract]; Representative immunohistochemistry (IHC) staining of UCP1 and H&E staining of sWAT. Captopril (40 mg/kg; once daily; 21 days; 25°C) induced sWAT brownin.

: Captopril hydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 May 2;14(1):2523. [Abstract]; Captopril (40 mg/kg; once daily; 21 days; 25°C) decreased the weight of sWAT in WT male mice.

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Beschreibung	Captopril (SQ 14225) hydrochloride, antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC₅₀=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril hydrochloride is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC₅₀ of 7.9 μM^[1]^[2]^[3].
IC₅₀ & Target	ACE^[1]
In Vitro	Captopril (SQ 14225) hydrochloride has been shown to have similar morbidity and mortality benefits to those of diuretics and beta-blockers in hypertensive patients. Captopril hydrochloride has been shown to delay the progression of diabetic nephropathy, and enalapril and lisinopril prevent the development of nephropathy in normoalbuminuric patients with diabetes^[4]. An equimolar ratio of the cis and trans states of Captopril hydrochloride exists in solution and that the enzyme selects only the trans state of the inhibitor that presents architectural and stereoelectronic complementarity with its substrate binding groove^[5]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Captopril hydrochloride Related Antibodies
Molekulargewicht	253.75
Formel	C₉H₁₆ClNO₃S
CAS. Nr.	198342-23-3
SMILES	O=C(O)[C@H]1N(C([C@H](C)CS)=O)CCC1.Cl
Versand	Room temperature in continental US; may vary elsewhere.
Speicherung	Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation	Data Sheet (274 KB) Handling Instructions (2659 KB)
Verweise	[1]. Afrin S, et al. Eritadenine from Edible Mushrooms Inhibits Activity of Angiotensin Converting Enzyme in Vitro. J Agric Food Chem. 2016;64(11):2263-2268. [Content Brief] [2]. Esmaeili S, et al. Captopril/enalapril inhibit promiscuous esterase activity of carbonic anhydrase at micromolar concentrations: An in vitro study. Chem Biol Interact. 2017;265:24-35. [Content Brief] [3]. Li N, et al. Simplified captopril analogues as NDM-1 inhibitors. Bioorg Med Chem Lett. 2014;24(1):386-389. [Content Brief] [4]. Tzakos, A.G., et al., The molecular basis for the selection of captopril cis and trans conformations by angiotensin I converting enzyme. Bioorg Med Chem Lett, 2006. 16(19): p. 5084-7. [Content Brief] [5]. Song, J.C. and C.M. White, Clinical pharmacokinetics and selective pharmacodynamics of new angiotensin converting enzyme inhibitors: an update. Clin Pharmacokinet, 2002. 41(3): p. 207-24. [Content Brief]

Captopril hydrochloride Related Classifications

Molaritätsrechner
Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Diese Gleichung wird häufig abgekürzt als: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Captopril198342-23-3SQ 14225SQ14225SQ-14225Angiotensin-converting Enzyme (ACE)antihypertensiveoralhypertensioncongestiveheartfailureInhibitorinhibitorinhibit

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Captopril hydrochloride (Synonyms: SQ 14225 hydrochloride)

Other Forms of Captopril hydrochloride:

Captopril hydrochloride Related Antibodies

22 Publications Citing Use of MCE Captopril hydrochloride

Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Biologische Aktivität

Reinheit & Dokumentation

Verweise

Kundenbewertung

Captopril hydrochloride Related Antibodies

Captopril hydrochloride Related Classifications

Molaritätsrechner

Verdünnungsrechner