198342-23-3
Chemical Structure
Captopril hydrochloride
Synonym(s): SQ 14225 hydrochloride
- CAS No.: 198342-23-3
- Formula:C9H16ClNO3S
- Molecular Weight:253.75
IUPAC Name: ((S)-3-mercapto-2-methylpropanoyl)-L-proline hydrochloride
InChIKey: FECNGFPXMFYVNI-HHQFNNIRSA-N
SMILES: O=C(O)[C@H]1N(C([C@H](C)CS)=O)CCC1.Cl
Biological Activity: Captopril (SQ 14225) hydrochloride, antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril hydrochloride is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC50 of 7.9 μM[1][2][3].
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Captopril hydrochloride | Captopril (SQ 14225) hydrochloride, antihypertensive agent, is a thiol-containing competitive, orally active angiotensin-converting enzyme (ACE) inhibitor (IC50=0.025 μM) and has been widely used for research of hypertension and congestive heart failure. Captopril hydrochloride is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC50 of 7.9 μM. | |||||||||||||||||||||
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- [1]. Afrin S, et al. Eritadenine from Edible Mushrooms Inhibits Activity of Angiotensin Converting Enzyme in Vitro. J Agric Food Chem. 2016;64(11):2263-2268. [Content Brief]
- [2]. Esmaeili S, et al. Captopril/enalapril inhibit promiscuous esterase activity of carbonic anhydrase at micromolar concentrations: An in vitro study. Chem Biol Interact. 2017;265:24-35. [Content Brief]
- [3]. Li N, et al. Simplified captopril analogues as NDM-1 inhibitors. Bioorg Med Chem Lett. 2014;24(1):386-389. [Content Brief]
Keywords
