1. Cell Cycle/DNA Damage
  2. CDK
  3. CDK4/6-IN-6

CDK4/6-IN-6 

Cat. No.: HY-139450
Handling Instructions

CDK4/6-IN-6 (example A94) is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively.

For research use only. We do not sell to patients.

CDK4/6-IN-6 Chemical Structure

CDK4/6-IN-6 Chemical Structure

CAS No. : 2380321-51-5

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Description

CDK4/6-IN-6 (example A94) is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively[1].

IC50 & Target[1]

Cdk4/cyclin D1

0.6 nM (Ki)

cdk6/cyclin D3

13.9 nM (Ki)

In Vitro

CDK4/6-IN-6 (example A94) has IC50s of 38.5 nM and 144.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3 using phospho-Rb S795 ELISA assays in JEKO-1 and MV4-1 1 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

463.93

Formula

C₂₂H₂₇ClFN₅O₃

CAS No.
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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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CDK4/6-IN-6
Cat. No.:
HY-139450
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