2. Anti-infection Apoptosis
  3. Fungal Ferroptosis Bacterial
  4. Ciclopirox olamine

Ciclopirox olamine  (Synonyms: Ciclopirox ethanolamine; HOE 296)

Cat. No.: HY-B0450AG
Instrucciones de manejo Technical Support

Ciclopirox (olamine) (GMP) is Ciclopirox olamine (HY-B0450A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Ciclopirox (HOE296b) is a synthetic antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic.

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Ciclopirox olamine

Ciclopirox olamine Estructura química

No. CAS : 41621-49-2

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Ciclopirox olamine Related Antibodies

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Descripciòn

Ciclopirox (olamine) (GMP) is Ciclopirox olamine (HY-B0450A) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Ciclopirox (HOE296b) is a synthetic antifungal agent that can be used for superficial mycoses reseaech. Ciclopirox olamine has a very broad spectrum of activity and inhibits dermatophytes, yeasts, molds, and many Gram-positive and Gram-negative species pathogenic[1].

Cellular Effect
Cell Line Type Value Description References
CHO IC50
> 40 3
Compound: CPX.Olamine
Inhibition of human ERG stably expressed in CHO cells at -80 mV by automated Qpatch electrophysiological assay
Inhibition of human ERG stably expressed in CHO cells at -80 mV by automated Qpatch electrophysiological assay
[PMID: 31910018]
CHO IC50
>40 3
Compound: CPX.Olamine
Inhibition of human ERG stably expressed in CHO cells at -80 mV by automated Qpatch electrophysiological assay
Inhibition of human ERG stably expressed in CHO cells at -80 mV by automated Qpatch electrophysiological assay
[PMID: 31910018]
HepG2 IC50
>100 3
Compound: 92125547
HARVARD: Cytotoxicity in HepG2 cell line
HARVARD: Cytotoxicity in HepG2 cell line
[PMID: 22586124]
HepG2 IC50
1.05 3
Compound: 92125547
HARVARD: Inhibition of liver stage Plasmodium berghei infection in HepG2 cells
HARVARD: Inhibition of liver stage Plasmodium berghei infection in HepG2 cells
[PMID: 22586124]
MRC5 IC50
23.47 3
Compound: CPX.Olamine
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
[PMID: 31910018]
SH-SY5Y IC50
>100 3
Compound: CPX.Olamine
Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
[PMID: 31910018]
HepG2 IC50
1.05 3
Compound: 92125547
HARVARD: Inhibition of liver stage Plasmodium berghei infection in HepG2 cells
HARVARD: Inhibition of liver stage Plasmodium berghei infection in HepG2 cells
[PMID: 22586124]
HepG2 IC50
> 100 3
Compound: 92125547
HARVARD: Cytotoxicity in HepG2 cell line
HARVARD: Cytotoxicity in HepG2 cell line
[PMID: 22586124]
MRC5 IC50
23.47 3
Compound: CPX.Olamine
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay
[PMID: 31910018]
SH-SY5Y IC50
> 100 3
Compound: CPX.Olamine
Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability measured after 24 hrs by MTT assay
[PMID: 31910018]
In Vitro

In a study conducted to further elucidate Ciclopirox GMP's mechanism, several Saccharomyces cerevisiae mutants were screened and tested. Results from interpretation of the effects of both the drug treatment and mutation suggested that Ciclopirox GMP may exert its effect by disrupting DNA repair, cell division signals and structures (mitotic spindles) as well as some elements of intracellular transport[2].
Ciclopirox GMP is a broad-spectrum antifungal with anti-inflammatory properties effective against the yeast implicated in seborrhoeic dermatitis, Malassezia spp[3].
Ciclopirox (olamine) (0.9 μM, 24 h) protects human iPSC-derived RPE cells exposed to TBHP-induced cell from oxidative damage[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ciclopirox olamine Related Antibodies

Cell Viability Assay[2]

Cell Line: iPSC-derived RPE cells
Concentration: 0.9 μM
Incubation Time: 24 h
Result: Protected human iPSC-derived RPE cells exposed to TBHP-induced cell death.

Real Time qPCR[2]

Cell Line: iPSC-derived RPE cells
Concentration: 0.9 μM
Incubation Time: 24 h
Result: Expressed RPE markers (RPE65, BEST1, MITF).
Peso molecular

268.35

Fòrmula

C14H24N2O3
No. CAS
SMILES

O=C1C=C(C)C=C(C2CCCCC2)N1O.NCCO
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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Ciclopirox olamine Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ciclopirox olamine (GMP)41621-49-2Ciclopirox ethanolamine (GMP) HOE 296 (GMP)FungalFerroptosisBacterialInhibitorinhibitorinhibit

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