Clodronate liposomes

Cat. No.: HY-172202: Data Sheet
COA

SDS
Handling Instructions
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Clodronate liposomes, a mixture of Clodronate encapsulated by phospholipids, is a macrophage scavenger. Clodronate liposomes is engulfed by macrophages in the body. Under the action of lysosomal phosphatases in macrophages, Clodronate dissolved in liposomes will be gradually released and accumulated in cells. When a certain concentration is reached, macrophages will be irreversibly damaged and apoptosis will be induced.

For research use only. We do not sell to patients.

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5 mL	In-stock	Estimated Time of Arrival: December 31
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Based on 9 publication(s) in Google Scholar

Other Forms of Clodronate liposomes:

Control Liposomes(PBS) In-stock

9 Publications Citing Use of MCE Clodronate liposomes

In Vivo Efficacy Study

Histological Imaging/Staining

: Clodronate liposomes purchased from MedChemExpress. Usage Cited in: Cell Oncol (Dordr). 2026 Mar 23;49(2):61. [Abstract]; Verification of macrophage deletion by Clodronate liposomes. Clodronate liposomes (40 mg/kg; i.p.) were administered twice weekly for two weeks before tumor inoculation and then weekly for four additional weeks. IF analysis of F4/80+ macrophages in the following groups: PBS-liposomes, ADM, Clodronateliposome, or ADM + Clodronate-liposome. Scale bar, 50 μm.

: Clodronate liposomes purchased from MedChemExpress. Usage Cited in: FASEB J. 2025 Aug 15;39(15):e70923. [Abstract]; Representative micro‐CT images showing new bone formation in each group. Both the YAP1 inhibitor group and the Clodronate liposomes group exhibited impaired bone regeneration compared to the Ctrl group.

: Clodronate liposomes purchased from MedChemExpress. Usage Cited in: FASEB J. 2025 Aug 15;39(15):e70923. [Abstract]; H&E staining and Masson's trichrome staining showed dense lamellar bone formation in the Ctrl group, while the YAP1 inhibitor and Clodronate liposomes groups exhibited sparse trabeculae, fibrous tissue infiltration, or immature callus.

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Purity & Documentation
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Description	Clodronate liposomes, a mixture of Clodronate encapsulated by phospholipids, is a macrophage scavenger. Clodronate liposomes is engulfed by macrophages in the body. Under the action of lysosomal phosphatases in macrophages, Clodronate dissolved in liposomes will be gradually released and accumulated in cells. When a certain concentration is reached, macrophages will be irreversibly damaged and apoptosis will be induced^[1].
In Vivo	Methods for clearing macrophages from different tissues (for reference only, can be optimized according to specific experiments) Clearing red pulp area of spleen and Kupffer macrophages: Single dose: 200 μL/mouse (intravenous or intraperitoneal injection). Long-term administration: The first dose is 150 μL/mouse, and then 100 μL/mouse every three days. Depletion of alveolar macrophages The best effect was obtained by intravenous injection (150-200 μL) combined with tracheal or intranasal administration (50 μL). Depletion of brain microglia Intraventricular cerebrospinal fluid injection, mice (10 μL), rats (50 μL). MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Appearance	Liquid
Color	Milky white to off-white
SMILES	[Clodronate liposomes]
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Store at 4°C, do not freeze
Purity & Documentation	Select Batch: Data Sheet (268 KB) SDS (251 KB) COA (241 KB) Handling Instructions (2659 KB)
References	[1]. Moreno SG. Depleting Macrophages In Vivo with Clodronate-Liposomes. Methods Mol Biol. 2018;1784:259-262. [Content Brief]