1. GPCR/G Protein
    Neuronal Signaling
  2. Neuropeptide Y Receptor
  3. CYM 9484

CYM 9484 

Cat. No.: HY-107735 Purity: >99.0%
Handling Instructions

CYM 9484 is a selective and highly potent neuropeptide Y (NPY) Y2 receptor antagonist with an IC50 value of 19 nM.

For research use only. We do not sell to patients.

CYM 9484 Chemical Structure

CYM 9484 Chemical Structure

CAS No. : 1383478-94-1

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 558 In-stock
Estimated Time of Arrival: December 31
5 mg USD 498 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

CYM 9484 is a selective and highly potent neuropeptide Y (NPY) Y2 receptor antagonist with an IC50 value of 19 nM[1].

IC50 & Target[1]

NPYY2 receptor

19 nM (IC50)

In Vitro

SF-11 is a selective, brain-penetrant NPY Y2 receptor antagonist with an IC50 value of 190 nM. Systematically explore the SAR of the hit molecule SF-11 that leads to the identification of selective and highly potent small molecule NPY Y2 receptor antagonist CYM 9484 (Compound 16). CYM 9484 is 10-fold more potent than the hit molecule SF-11. CYM 9484 is prepared by the coupling of α,α-diphenylpiperidino-4-methanol with a variety of aryl isothiocyanates[1].

Molecular Weight

509.68

Formula

C₂₇H₃₁N₃O₃S₂

CAS No.

1383478-94-1

SMILES

OC(C1=CC=CC=C1)(C2=CC=CC=C2)C3CCN(C(NC4=CC=C(S(N(C)C)(=O)=O)C=C4)=S)CC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

CYM 9484CYM9484CYM-9484Neuropeptide Y ReceptorNPY receptorSARsynthesissmallmoleculesInhibitorinhibitorinhibit

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CYM 9484
Cat. No.:
HY-107735
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