Dansyl-Tyr-Val-Gly

Name: Dansyl-Tyr-Val-Gly
Brand: MedChemExpress
SKU: HY-138126
Rating: 4.5 (0 reviews)

Art. -Nr.: HY-138126 Reinheit: 99.53%: Data Sheet
COA

SDS
Handling Instructions
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Technical Support

Dansyl-Tyr-Val-Gly is a substrate of peptidylglycine monooxygenase (PHM), with a K_D of 22 μM for PHM. Dansyl-Tyr-Val-Gly can be used to investigate the catalytic mechanism, kinetics and inactivation characteristics of PHM.

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Kundenspezifische Peptidsynthese

Dansyl-Tyr-Val-Gly Chemische Struktur

CAS. Nr. : 113527-49-4

Größe	Verfügbarkeit	Menge
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	Auf Lager	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	Auf Lager	Estimated Time of Arrival: December 31
Solid
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Auf Lager	Estimated Time of Arrival: December 31
25 mg	Auf Lager	Estimated Time of Arrival: December 31
50 mg	Auf Lager	Estimated Time of Arrival: December 31
100 mg	Angebot einholen
200 mg	Angebot einholen

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Other Forms of Dansyl-Tyr-Val-Gly:

Dansyl-Tyr-Val-Gly TFA Angebot einholen

Spezialitätsempfehlungen

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biologische Aktivität
Reinheit & Dokumentation
Verweise
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Beschreibung

In Vitro

Dansyl-Tyr-Val-Gly (15-25 μM) protects recombinant type A rat 75 kDa α-AE against ascorbate-mediated inactivation of its peptidyl-Gly hydroxylase activity and serves as a substrate for α-AE-mediated amidation to quantify residual enzyme activity^[2].
Dansyl-Tyr-Val-Gly (15 μM) supports amidation with ascorbate as a reductant, which has an apparent K_m of 0.20 mM and a relative V_m,app of 100% when incubated with recombinant type A rat 75 kDa α-AE^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molekulargewicht

570.66

Formel

C₂₈H₃₄N₄O₇S

CAS. Nr.

113527-49-4

Appearance

Solid

Color

Off-white to light yellow

Sequence Shortening

Dansyl-YVG

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 100 mg/mL (175.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7524 mL	8.7618 mL	17.5236 mL
5 mM	0.3505 mL	1.7524 mL	3.5047 mL
10 mM	0.1752 mL	0.8762 mL	1.7524 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 99.53%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (251 KB) RP-HPLC (113 KB) MS (212 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Welch EF, et al. Pre-Steady-State Reactivity of Peptidylglycine Monooxygenase Implicates Ascorbate in Substrate Triggering of the Active Conformer. Biochemistry. 2022;61(8):665-677. [Content Brief]

[2]. Merkler DJ, et al. Selective inactivation of the hydroxylase activity of bifunctional rat peptidylglycine alpha-amidating enzyme. Arch Biochem Biophys. 1992;294(2):594-602. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7524 mL	8.7618 mL	17.5236 mL	43.8089 mL
	5 mM	0.3505 mL	1.7524 mL	3.5047 mL	8.7618 mL
	10 mM	0.1752 mL	0.8762 mL	1.7524 mL	4.3809 mL
	15 mM	0.1168 mL	0.5841 mL	1.1682 mL	2.9206 mL
	20 mM	0.0876 mL	0.4381 mL	0.8762 mL	2.1904 mL
	25 mM	0.0701 mL	0.3505 mL	0.7009 mL	1.7524 mL
	30 mM	0.0584 mL	0.2921 mL	0.5841 mL	1.4603 mL
	40 mM	0.0438 mL	0.2190 mL	0.4381 mL	1.0952 mL
	50 mM	0.0350 mL	0.1752 mL	0.3505 mL	0.8762 mL
	60 mM	0.0292 mL	0.1460 mL	0.2921 mL	0.7301 mL
	80 mM	0.0219 mL	0.1095 mL	0.2190 mL	0.5476 mL
	100 mM	0.0175 mL	0.0876 mL	0.1752 mL	0.4381 mL