2. Immunology/Inflammation Antibody-drug Conjugate/ADC Related
  3. CD38 ADC Antibody
  4. Daratumumab

Daratumumab  (Synonyms: Anti-Human CD38, Human Antibody; HuMax-CD38; JNJ-54767414)

Cat. No.: HY-P9915 Pureza: 99.10%
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Daratumumab (Anti-Human CD38) is the first-in-class human-specific anti-CD38 monoclonal antibody (IgG1). Daratumumab has anti-multiple myeloma (MM) effect. Daratumumab impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition.

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No. CAS : 945721-28-8

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Revisión del cliente

Based on 11 publication(s) in Google Scholar

Other Forms of Daratumumab:

Daratumumab Related Antibodies

Top Publications Citing Use of Products

    Daratumumab purchased from MedChemExpress. Usage Cited in: Nat Biotechnol. 2025 Oct 17.  [Abstract]

    A single mesodermal tumor was injected into mesodermal CAR-T cells, and the following treatments were administered: untreated group, daratumumab (0.5 or 10 μg/ml) treatment group, or IgG isotype control antibody (10 μg/ml IgG) treatment group. The change in T cell area over time was quantitatively analyzed.

    Daratumumab purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2025 Oct 7;82(1):352.  [Abstract]

    ADCC in H929 cells caused by various concentration of Dara (Daratumumab, 1h treatment and 4h NK cell co-culture).

    Daratumumab purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2025 Oct 7;82(1):352.  [Abstract]

    Compared with vehicle control, Dara (Daratumumab, i.p. 8 mg/kg per mouse weekly for 3w) cause significantly reduction of xenograft tumors weight and tumor growth.

    Daratumumab purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2025 Oct 7;82(1):352.  [Abstract]

    Inhibitor of ALDH1A 673 A remarkably reduce the protein level of CD38, ALDH1A1 and RAR, and RA complement significantly restore the protein level of CD38 and RAR. Dara (Daratumumab, i.p. 8 mg/kg per mouse weekly for 3w).

    Daratumumab purchased from MedChemExpress. Usage Cited in: Clin Cancer Res. 2023 Aug 15;29(16):2988-3003.  [Abstract]

    ADCC capability of INBRX-109 was evaluated in the Promega Jurkat CD16a (V158) ADCC reporter assay using DR5-transfected ExpiCHO-S cells as targets and untransfected cells as negative controls. Daratumumab (5.5 h), the target of which is expressed on Jurkat cells, serves as a positive control.

    Daratumumab purchased from MedChemExpress. Usage Cited in: Clin Cancer Res. 2023 Aug 15;29(16):2988-3003.  [Abstract]

    The ability of INBRX-109 to bind the complement component C1q contained within normal human serum was measured by ELISA. Daratumumab (5.5 h) is used as a positive control.

    • Actividad biológica

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    • Revisión del cliente

    Descripciòn

    Daratumumab (Anti-Human CD38) is the first-in-class human-specific anti-CD38 monoclonal antibody (IgG1). Daratumumab has anti-multiple myeloma (MM) effect. Daratumumab impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition[1][2].

    Isotype

    Human IgG1 kappa
    Recommend Isotype Controls
    Species Reactivity

    Human
    IC50 & Target

    CD38
    In Vitro

    Daratumumab (Anti-Human CD38) induces potent Ab-dependent cellular cytotoxicity in CD38-expressing lymphoma- and MM-derived cell lines[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Daratumumab Related Antibodies
    In Vivo

    Daratumumab (i.p.; 0.5 mg/kg; 14 d after challenge with Daudi-luc cells) inhibits outgrowth of CD38-expressing tumor cells in mouse xenograft tumor models[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: 8- to 10-wk-old C.B-17 SCID mice (luciferase-expressing Daudi cells)[2]
    Dosage: 0.5 mg/kg
    Administration: I.p.; 14 day after challenge with Daudi-luc cells
    Result: Effectively inhibited tumor growth compared with control-treated animals in which tumor grew rapidly and therefore required euthanasia on day 35. On day 28 and day 35, tumor size in Daratumumab-treated animals was significantly different from the control.
    Ensayo clínico
    Gene ID

    952  [NCBI]

    Accession
    Application

    ELISA, FACS, Functional assay
    Conjugated

    Unconjugated
    Reconsititution

    The product can be reconstituted/diluted with sterile PBS or saline.
    Peso molecular

    145.26 kDa

    No. CAS
    Appearance

    Liquid

    Color

    Colorless to light yellow

    SMILES

    [Daratumumab]
    Formulation

    Please refer to the lot-specific COA for specific buffer information.
    Almacenamiento

    Please store the product under the recommended conditions in the Certificate of Analysis.
    Format
    • Human IgG1 kappa
    Biological Activity
    • Flow cytometry analysis of Raji cells labelling CD38 with Daratumumab at 100nM (Red). Goat anti human IgG Fc(Alexa Fluor488) was used as the secondary antibody at 1/400 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).
    • Daratumumab has a significant CDC effect on Raji cells in a dose-dependent manner. The EC50 for this effect is 96.2 and 98.6 ng/mL.
    Pureza y Documentación

    Purity: 99.10%

    SDS (252 KB)

    COA (232 KB)

    Inhibitory Antibodies User Guide (603 KB)
    Referencias
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    • If you have published this work, please enter the PubMed ID.
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    Daratumumab Related Classifications

    • Calculadora de molaridad

    • Calculadora de dilución

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Daratumumab945721-28-8Anti-Human CD38, Human Antibody HuMax-CD38 JNJ-54767414JNJ54767414JNJ 54767414JNJ-54767414CD38ADC AntibodymyelomacelladhesioncytotoxicitytumorMMNKantibodyInhibitorinhibitorinhibit

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    Inquiry Information

    Nombre del producto:
    Daratumumab
    Cat. No.:
    HY-P9915
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    MCE Japan Authorized Agent:

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