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Daratumumab (Anti-CD38)

(Synonyms: Anti-Human CD38, Human Antibody (PBS))
11 Cited Publications
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Based on 11 publication(s) in Google Scholar

Daratumumab (PBS) (Anti-Human CD38) is the first-in-class human-specific anti-CD38 monoclonal antibody (IgG1). Daratumumab (PBS) has anti-multiple myeloma (MM) effect. Daratumumab (PBS) impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition.

For research use only. We do not sell to patients.

  • Purity: 97.94%
  • CAS No.: 945721-28-8
  • Molecular Weight:145.26 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Daratumumab (Anti-CD38)
  • Experimental Validation Results for Daratumumab (Anti-CD38)
  • Experimental Validation Results for Daratumumab (Anti-CD38)
  • Experimental Validation Results for Daratumumab (Anti-CD38)
  • Experimental Validation Results for Daratumumab (Anti-CD38)
  • Experimental Validation Results for Daratumumab (Anti-CD38)
  • Experimental Validation Results for Daratumumab (Anti-CD38)
  • Experimental Validation Results for Daratumumab (Anti-CD38)
  • Daratumumab (Anti-CD38) Chemical Structure
    Daratumumab (Anti-CD38) Chemical Structure
CAS No.: 945721-28-8
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609-228-6898
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Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Flow Cytometry analysis of Raji cells labelling CD38 (red) with Daratumumab (anti-CD38) (HY-P9915A). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.

  • 1/16

    Daratumumab (Anti-CD38) purchased from MedChemExpress. Usage Cited in: Nat Biotechnol. 2025 Oct 17. [Abstract]

    Customer Validation
     A single mesodermal tumor was injected into mesodermal CAR-T cells, and the following treatments were administered: untreated group, daratumumab (0.5 or 10 μg/ml) treatment group, or IgG isotype control antibody (10 μg/ml IgG) treatment group. The change in T cell area over time was quantitatively analyzed.

  • 1/16

    Daratumumab (Anti-CD38) purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2025 Oct 7;82(1):352. [Abstract]

    Customer Validation
     ADCC in H929 cells caused by various concentration of Dara (Daratumumab, 1h treatment and 4h NK cell co-culture).

  • 1/16

    Daratumumab (Anti-CD38) purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2025 Oct 7;82(1):352. [Abstract]

    Customer Validation
     Compared with vehicle control, Dara (Daratumumab, i.p. 8 mg/kg per mouse weekly for 3w) cause significantly reduction of xenograft tumors weight and tumor growth.

  • 1/16

    Daratumumab (Anti-CD38) purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2025 Oct 7;82(1):352. [Abstract]

    Customer Validation
     Inhibitor of ALDH1A 673 A remarkably reduce the protein level of CD38, ALDH1A1 and RAR, and RA complement significantly restore the protein level of CD38 and RAR. Dara (Daratumumab, i.p. 8 mg/kg per mouse weekly for 3w).

  • 1/16

    Daratumumab (Anti-CD38) purchased from MedChemExpress. Usage Cited in: Clin Cancer Res. 2023 Aug 15;29(16):2988-3003. [Abstract]

    Customer Validation
     ADCC capability of INBRX-109 was evaluated in the Promega Jurkat CD16a (V158) ADCC reporter assay using DR5-transfected ExpiCHO-S cells as targets and untransfected cells as negative controls. Daratumumab (5.5 h), the target of which is expressed on Jurkat cells, serves as a positive control.

  • 1/16

    Daratumumab (Anti-CD38) purchased from MedChemExpress. Usage Cited in: Clin Cancer Res. 2023 Aug 15;29(16):2988-3003. [Abstract]

    Customer Validation
     The ability of INBRX-109 to bind the complement component C1q contained within normal human serum was measured by ELISA. Daratumumab (5.5 h) is used as a positive control.

  • Daratumumab (Anti-CD38) Chemical Structure
    1/16
  • Daratumumab (Anti-CD38)
  • Flow Cytometry analysis of Raji cells labelling CD38 (red) with Daratumumab (anti-CD38) (HY-P9915A). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.