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Daratumumab (Anti-CD38)

(Synonyms: Anti-Human CD38, Human Antibody (PBS))
12 Cited Publications
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Based on 12 publication(s) in Google Scholar

Daratumumab (PBS) (Anti-Human CD38) is the first-in-class human-specific anti-CD38 monoclonal antibody (IgG1). Daratumumab (PBS) has anti-multiple myeloma (MM) effect. Daratumumab (PBS) impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition.

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  • Reinheit: 97.94%
  • CAS. Nr.: 945721-28-8
  • Molecular Weight:145.26 kDa
  • Speicherung:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Daratumumab (Anti-CD38)
  • Experimental Validation Results for Daratumumab (Anti-CD38)
  • Experimental Validation Results for Daratumumab (Anti-CD38)
  • Experimental Validation Results for Daratumumab (Anti-CD38)
  • Experimental Validation Results for Daratumumab (Anti-CD38)
  • Experimental Validation Results for Daratumumab (Anti-CD38)
  • Experimental Validation Results for Daratumumab (Anti-CD38)
  • Experimental Validation Results for Daratumumab (Anti-CD38)
  • Daratumumab (Anti-CD38) Chemical Structure
    Daratumumab (Anti-CD38) Chemical Structure
CAS. Nr.: 945721-28-8
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Publications Citing Use of MedChemExpress (MCE) Daratumumab (Anti-CD38)

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In Vivo Efficacy StudyCell Proliferation/Viability AssayBio/Physico-chemical AssayWB
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  • Cell Proliferation/Viability Assay
  • In Vivo Efficacy Study
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Flow Cytometry analysis of Raji cells labelling CD38 (red) with Daratumumab (anti-CD38) (HY-P9915A). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.

  • 1/16

    Daratumumab (Anti-CD38) purchased from MedChemExpress. Usage Cited in: Nat Biotechnol. 2025 Oct 17. [Abstract]

    Customer Validation
     A single mesodermal tumor was injected into mesodermal CAR-T cells, and the following treatments were administered: untreated group, daratumumab (0.5 or 10 μg/ml) treatment group, or IgG isotype control antibody (10 μg/ml IgG) treatment group. The change in T cell area over time was quantitatively analyzed.

  • 1/16

    Daratumumab (Anti-CD38) purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2025 Oct 7;82(1):352. [Abstract]

    Customer Validation
     ADCC in H929 cells caused by various concentration of Dara (Daratumumab, 1h treatment and 4h NK cell co-culture).

  • 1/16

    Daratumumab (Anti-CD38) purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2025 Oct 7;82(1):352. [Abstract]

    Customer Validation
     Compared with vehicle control, Dara (Daratumumab, i.p. 8 mg/kg per mouse weekly for 3w) cause significantly reduction of xenograft tumors weight and tumor growth.

  • 1/16

    Daratumumab (Anti-CD38) purchased from MedChemExpress. Usage Cited in: Cell Mol Life Sci. 2025 Oct 7;82(1):352. [Abstract]

    Customer Validation
     Inhibitor of ALDH1A 673 A remarkably reduce the protein level of CD38, ALDH1A1 and RAR, and RA complement significantly restore the protein level of CD38 and RAR. Dara (Daratumumab, i.p. 8 mg/kg per mouse weekly for 3w).

  • 1/16

    Daratumumab (Anti-CD38) purchased from MedChemExpress. Usage Cited in: Clin Cancer Res. 2023 Aug 15;29(16):2988-3003. [Abstract]

    Customer Validation
     ADCC capability of INBRX-109 was evaluated in the Promega Jurkat CD16a (V158) ADCC reporter assay using DR5-transfected ExpiCHO-S cells as targets and untransfected cells as negative controls. Daratumumab (5.5 h), the target of which is expressed on Jurkat cells, serves as a positive control.

  • 1/16

    Daratumumab (Anti-CD38) purchased from MedChemExpress. Usage Cited in: Clin Cancer Res. 2023 Aug 15;29(16):2988-3003. [Abstract]

    Customer Validation
     The ability of INBRX-109 to bind the complement component C1q contained within normal human serum was measured by ELISA. Daratumumab (5.5 h) is used as a positive control.

  • Daratumumab (Anti-CD38) Chemical Structure
    1/16
  • Daratumumab (Anti-CD38)
  • Flow Cytometry analysis of Raji cells labelling CD38 (red) with Daratumumab (anti-CD38) (HY-P9915A). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.