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Daratumumab (Synonyms: Anti-Human CD38, Human Antibody)

Cat. No.: HY-P9915
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Daratumumab (Anti-Human CD38) is the first-in-class human-specific anti-CD38 monoclonal antibody. Daratumumab has anti-multiple myeloma (MM) effect. Daratumumab impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition.

For research use only. We do not sell to patients.

Daratumumab Chemical Structure

Daratumumab Chemical Structure

CAS No. : 945721-28-8

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Description

Daratumumab (Anti-Human CD38) is the first-in-class human-specific anti-CD38 monoclonal antibody. Daratumumab has anti-multiple myeloma (MM) effect. Daratumumab impairs MM cell adhesion, which results in an increased sensitivity of MM to proteasome inhibition[1][2].

In Vitro

Daratumumab (Anti-Human CD38) induces potent Ab-dependent cellular cytotoxicity in CD38-expressing lymphoma- and MM-derived cell lines[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Daratumumab (i.p.; 0.5 mg/kg; 14 d after challenge with Daudi-luc cells) inhibits outgrowth of CD38-expressing tumor cells in mouse xenograft tumor models[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8- to 10-wk-old C.B-17 SCID mice (luciferase-expressing Daudi cells)[2]
Dosage: 0.5 mg/kg
Administration: I.p.; 14 day after challenge with Daudi-luc cells
Result: Effectively inhibited tumor growth compared with control-treated animals in which tumor grew rapidly and therefore required euthanasia on day 35. On day 28 and day 35, tumor size in Daratumumab-treated animals was significantly different from the control.
CAS No.
SMILES

[Daratumumab]

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Keywords:

DaratumumabAnti-Human CD38, Human AntibodyOthersmyelomacelladhesioncytotoxicitytumorMMNKantibodyInhibitorinhibitorinhibit

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