2. Apoptosis
  3. Apoptosis
  4. DB2313 tetrahydrochloride

DB2313 tetrahydrochloride is a potent transcription factor PU.1 inhibitor with an apoptosis of 14 nM. DB2313 tetrahydrochloride disrupts the interaction of PU.1 with target gene promoters. DB2313 tetrahydrochloride induces apoptosis of acute myeloid leukemia (AML) cells, and has anticancer effects.

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CAS. Nr. : 2170606-75-2

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Top Publications Citing Use of Products

    DB2313 tetrahydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Aug 4;16(1):7134.  [Abstract]

    DB2313 (660 nM) inhibited the transcription of CSF1R, CALM1, and SLC2A3 while promoting E2F in neutrophils.

    DB2313 tetrahydrochloride purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Aug 4;16(1):7134.  [Abstract]

    DB2313 (17 mg/kg; i.p.) decreased serum levels of MMP9 and MPO/DNA‐NETs in the murine MI/RI model.

    DB2313 tetrahydrochloride purchased from MedChemExpress. Usage Cited in: Ann Rheum Dis. 2024 Aug 20:ard-2024-226067.  [Abstract]

    DB2313 (0.3 mg; i.p.; once every 3 d) downregulated IL-9 expression and the proportions of Th9 cells in the spleen and PBMCs of collagen-induced arthritis (CIA) mice.

    DB2313 tetrahydrochloride purchased from MedChemExpress. Usage Cited in: Ann Rheum Dis. 2024 Aug 20:ard-2024-226067.  [Abstract]

    PU.1 inhibitor DB2313 (0.3 mg; i.p.; once every 3 d) suppressed IL-9 release from Th9 cells of collagen-induced arthritis (CIA) mice.

    DB2313 tetrahydrochloride purchased from MedChemExpress. Usage Cited in: Ann Rheum Dis. 2024 Aug 20:ard-2024-226067.  [Abstract]

    Effect of PU.1 inhibitor DB2313 (0.3 mg; i.p.; once every 3 d) on joint neovascularization in collagen-induced arthritis (CIA) mice.

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    Beschreibung

    DB2313 tetrahydrochloride is a potent transcription factor PU.1 inhibitor with an apoptosis of 14 nM. DB2313 tetrahydrochloride disrupts the interaction of PU.1 with target gene promoters. DB2313 tetrahydrochloride induces apoptosis of acute myeloid leukemia (AML) cells, and has anticancer effects[1].

    Molekulargewicht

    854.67

    Formel

    C42H45Cl4FN8O2
    CAS. Nr.
    SMILES

    FC1=C(COC2=CC=C(C3=NC4=CC=C(C(NC(C)C)=N)C=C4N3)C=C2)C=CC=C1COC5=CC=C(C6=NC7=CC=C(C(NC(C)C)=N)C=C7N6)C=C5.Cl.Cl.Cl.Cl
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    Room temperature in continental US; may vary elsewhere.
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    DB2313 tetrahydrochloride Related Classifications

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    Keywords:

    DB2313 tetrahydrochloride2170606-75-2ApoptosisPU.1DNAanticanceracutemyeloidleukemiaInhibitorinhibitorinhibit

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